23042-77-5

Basic information

• Product Name: 1-(2-Amino-5-methoxy-phenyl)-ethanone
• Synonyms: Acetophenone, 2'-amino-5'-methoxy- (8CI);2'-Amino-5'-methoxyacetophenone
• CAS NO: 23042-77-5
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 23042-77-5.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 428.326 °C at 760 mmHg
• Flash Point: 219.55 °C
• Appearance: /
• Density: 1.172 g/cm³
• CAS DataBase Reference: 1-(2-Amino-5-methoxy-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Amino-5-methoxy-phenyl)-ethanone(23042-77-5)
• EPA Substance Registry System: 1-(2-Amino-5-methoxy-phenyl)-ethanone(23042-77-5)

Safety Data

• Hazardous Substances Data: 23042-77-5(Hazardous Substances Data)

Usage

General Description

1-(2-Amino-5-methoxy-phenyl)-ethanone is a chemical compound with the molecular formula C9H11NO2. It is also known by the name "5-Methoxy-2-aminoacetophenone" and is a derivative of acetophenone. 1-(2-Amino-5-methoxy-phenyl)-ethanone is used in organic synthesis and pharmaceutical research as a building block for the preparation of various pharmaceutical products. It has also been studied for its potential biological activities and has shown to possess antimicrobial and anticancer properties. Additionally, 1-(2-Amino-5-methoxy-phenyl)-ethanone has been used in the development of new drug candidates for the treatment of various diseases.

Upstream product

• 104-94-9 4-methoxy-aniline 
• 75-05-8 acetonitrile 
• 51-66-1 4-methoxyacetanilide 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 214957-88-7 2-{[(benzyloxy)carbonyl]amino}-5-hydroxybenzoic acid 
• 214971-08-1 benzyl 4-methoxy-2-(methoxy(methyl)carbamoyl)phenylcarbamate 
• 1335060-61-1 methyl 2-(benzyloxycarbonylamino)-5-methoxybenzoate 
• 1335060-62-2 benzyl 2-acetyl-4-methoxyphenylcarbamate 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 121-71-1 3-Hydroxyacetophenone 
• 52417-34-2 N-(2-acetyl-4-methoxyphenyl)acetamide 
• 23842-82-2 2-amino-5-methoxybenzonitrile 
• 75-16-1 methylmagnesium bromide 
• 917-54-4 methyllithium 

Downstream Products

• 143370-20-1 6-(2-acetyl-4-methoxy-phenylamino)quinoline-5,8-dione 
• 156785-64-7 2-<(4-fluorobenzoyl)amino>-5-methoxyacetophenone 
• 156785-63-6 5-methoxy-2-<(4-methoxybenzoyl)amino>acetophenone 
• 675578-58-2 N-(2-acetyl-4-methoxyphenyl)-4-methylbenzenesulfonamide 
• 801235-15-4 2-acetyl-6-chloro-p-anisidine 
• 134019-42-4 2-Amino-5-methoxyacetophenone phenylhydrazone 
• 30954-71-3 2′-amino-5′-hydroxyacetophenone 
• 1334951-19-7 5-methoxy-3-methyl-2-p-tolyl-2H-indazole 
• 848142-77-8 3-methyl-5-methoxy-2-(4-methoxyphenyl)-2H-indazole 
• 1335060-66-6 3-(1-(tert-butyldiphenylsilyloxy)ethyl)-6-methoxy-4-methylquinoline 
• 1335060-67-7 allyl 3-(1-allyloxycarbonyloxyethyl)-6-methoxy-4-methyl-2-(2-phenylethynyl)quinoline-1(2H)-carboxylate 
• 1335060-69-9 allyl 3-(1-acetoxyethyl)-6-methoxy-4-methyl-2-(2-phenylethynyl)quinoline-1(2H)-carboxylate 
• 1335060-70-2 allyl 6-methoxy-4-methyl-2-(2-phenylethynyl)-3-(1-pivaloyloxyethyl)quinoline-1(2H)-carboxylate 
• 1335060-71-3 allyl 3-(1-(tert-butyldiphenylsilyloxy)ethyl)-6-methoxy-4-methyl-2-(2-phenylethynyl)quinoline-1(2H)-carboxylate 

Relevant articles and documents

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Auto-tandem PET and EnT photocatalysis by crude chlorophyll under visible light towards the oxidative functionalization of indoles

Chlorophyll is the most abundant photocatalytic pigment that enables plants to absorb solar energy and convert it to energy storage molecules. Herein, we report a tandem photocatalytic approach utilizing the natural pigment chlorophyll in crude form to achieve photoinduced electron transfer (PET) and energy transfer (EnT) towards the oxidative functionalization of indoles. Redox potentials, ESR, fluorescence quenching and UV experiments have evidenced the dual catalytic activity of chlorophyll. The highlight of the study is the auto-tandem photocatalytic role of chlorophyll to enable the green oxidation of indoles using molecular oxygen as the oxidant, water as the reaction medium, and photochemical energy from the visible region of the spectrum.

Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks

Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.