23077-42-1

Basic information

• Product Name: 1H-INDOLE-3-CARBOXYLIC ACID,4-FLUORO-
• Synonyms: 1H-INDOLE-3-CARBOXYLIC ACID,4-FLUORO-;4-Fluoro-indole-3-carboxylic acid;4-Fluoro-1H-indole-3-carboxylic acid;Indole-3-carboxylic acid, 4-fluoro-
• CAS NO: 23077-42-1
• Molecular Formula: C₉H₆FNO₂
• Molecular Weight: 179.15
• Mol File: 23077-42-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 422.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.510±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.21±0.10(Predicted)
• CAS DataBase Reference: 1H-INDOLE-3-CARBOXYLIC ACID,4-FLUORO-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE-3-CARBOXYLIC ACID,4-FLUORO-(23077-42-1)
• EPA Substance Registry System: 1H-INDOLE-3-CARBOXYLIC ACID,4-FLUORO-(23077-42-1)

Safety Data

• Hazardous Substances Data: 23077-42-1(Hazardous Substances Data)

Usage

General Description

4-Fluoro-1H-indole-3-carboxylic Acid is a chemical compound that belongs to the class of organic compounds known as fluoroindoles, which are a type of aromatic heteropolycyclic compound. The molecule is composed of an indole ring fluorinated at position 4 and carboxylated at position 3. Fluorine atom in the molecular structure alters the chemical and physical properties, often enhancing the biological activity of these compounds. This particular compound is frequently used in research and development activities, particularly in the field of medicinal chemistry where it serves as a building block for more complex chemical structures.

Upstream product

• 1313044-12-0 2,2,2-trifluoro-1-(4-fluoro-1H-indol-3-yl)ethanone 
• 23073-31-6 (4-fluoroindol-3-yl)carboxaldehyde 
• 387-43-9 4-fluoroindole 

Relevant articles and documents

PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF

The present invention discloses a pyrimidine compound, a preparation method thereof and a medical use thereof. Specifically, the present invention discloses a pyrimidine compound represented by formula (I), pharmaceutically acceptable salts thereof, a preparation method thereof, and a use thereof as a cyclin-dependent kinase 9 (CDK9) inhibitor, particularly for the treatment of cancer. The definition of each group in formula (I) is the same as that in the specification.

Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties

Antibacterials that disrupt cell membrane function have the potential to eradicate “persister” organisms and delay the emergence of resistance. Here we report the antimycobacterial activities of 4-fluoro and 6-methoxyindoles bearing a cationic amphiphilic motif represented by a lipophilic n-octyl side chain at position 1 and a positively charged azepanyl or 1,4-dioxa-8-azaspiro[4.5]decane moiety at position 3. These analogues exhibited balanced profiles of potency (Mycobacterium bovis BCG, M tuberculosis H37Rv), selective activity, solubility, and metabolic stability. Bacteriological mechanism of action investigations on a representative analogue revealed cell membrane permeabilization and depolarization in M bovis BCG. These membrane-related changes preceded cell death indicating that the loss in membrane integrity was not an epiphenomenon. Bactericidal activity was observed against both growing and nongrowing mycobacterial cultures. The analogue also upregulated cell envelope stress-inducible promoters piniBAC and pclgR, implicating the involvement of envelope-related targets in its mode of action.