2309-49-1Relevant articles and documents
Electrochemical behaviour of 9-methylcaffeinium iodide and in situ electrochemical synthesis of hymeniacidin
Pandolfi, Fabiana,Mattiello, Leonardo,Zane, Daniela,Feroci, Marta
, p. 71 - 76 (2018)
9-Methylcaffeinium iodide, a bio-based salt obtained by reaction of caffeine with methyl iodide, is an imidazolium salt. The electrochemical behaviour of 9-methylcaffeinium iodide was studied by means of cyclic voltammetry, differential pulse voltammetry and electrolysis. Its behaviour revealed to be very similar to that of common imidazolium salts. In fact, its cathodic reduction yielded the corresponding N-heterocyclic carbene, which was evidenced by its reaction products with dioxygen and with sulfur, although in low amounts. In fact, this electrogenerated carbene was very unstable and prone to add water, yielding a ring opening product (hymeniacidin) in high yield. Hymeniacidin is a natural product from the marine sponge Hymeniacidon sp. The voltammetric behaviour of isolated hymeniacidin confirmed the in situ formation of this ring opening product, by comparison of the voltammetric peak potentials of starting caffeinium salt and hymeniacidin. This study allowed to determine that hymeniacidin derives from NHC, and not by hydrolysis of the caffeinium salt.
Synthesis method of tetramethyluric acid and special catalyst thereof
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Paragraph 0045-0049, (2020/09/16)
The invention discloses a synthesis method of tetramethyluric acid. The preparation method comprises the following steps: adding dimethyl carbonate, ionized water and a catalyst into a reaction kettle, stirring and heating to 160 DEG C, adding preheated uric acid into the reaction kettle, increasing the stirring speed, and starting reaction. The reaction conditions are as follows: under the actionof a catalyst, the temperature is 160-180 DEG C, the pressure is normal pressure, and the reaction time is 3-4 hours. The catalyst is a ruthenium-containing catalyst. According to the invention, synthesis of tetramethyluric acid under normal pressure is realized. In the production process, energy consumption can be reduced, and the requirement for equipment is lowered.
A natural product four methyl uric acid fully synthetic method
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, (2017/08/25)
The invention relates to a total synthesis method for a natural product tetramethyl uric acid. The method comprises the following steps: (1) using 1,3-dimethyl barbituric acid as a raw material for synthesis to obtain an intermediate 6-substitued-1,3-dimethyl pyrimidine-2,4-diketone; (2) synthesizing an intermediate 1,3-dimethyl-6-methylamino pyrimidine-2,4-diketone; (3) synthesizing an intermediate 1,3-dimethyl-5-substitued-6-methylamino pyrimidine-2,4-diketone; (4) synthesizing an intermediate 1,3-dimethyl-5,6-dimethylamino pyrimidine-2,4-diketone; (5) synthesizing a target compound 1,3,7,9-tetramethyl uric acid. The method is convenient for synthesis, has a higher yield, and can ease the demand on tetramethyl products to a certain degree.
