23107-96-2Relevant articles and documents
A microfluidic photoreactor enables 2-methylbenzophenone light-driven reactions with superior performance
Mateos, Javier,Cherubini-Celli, Alessio,Carofiglio, Tommaso,Bonchio, Marcella,Marino, Nadia,Companyó, Xavier,Dell'Amico, Luca
, p. 6820 - 6823 (2018)
Light-driven reactions of 2-methylbenzophenones (2-MBPs) occur with improved yields (up to >98%) and reaction rates (up to 0.240 mmol h-1) by using a tailored microfluidic photoreactor (MFP). For the first time, coumarins were converted into 4-
Synthesis of Tofisopam by Way of Photoinduced CO2 Fixation
Masuda, Yusuke,Makita, Katsuhiko,Ishida, Naoki,Murakami, Masahiro
supporting information, p. 4189 - 4192 (2019/11/26)
Herein reported is a unique synthetic route of Tofisopam, an anxiolytic drug containing a 2,3-benzodiazepine core structure. 3,4-Dimethoxypropylbenzene and 3,4-dimethoxybenzoic acid, which are both of plant origin, and CO2 constitute its carbon skeleton. These three renewable substances are united by two C?C bond forming reactions, i.e., a Friedel–Crafts acylation reaction and a photoinduced carboxylation reaction to construct the major carbon framework. Finally, a methyl group is introduced by a Kumada-type cross-coupling reaction to furnish Tofisopam. Various analogs of Tofisopam are readily synthesized by introducing other substituents than a methyl group at the last C?C bond forming step.
GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS
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Page/Page column 27, (2010/11/30)
This invention relates to a compound of formula (I) wherein the variables are as defined in the specification. The compound is useful for the treatment of gastrin related disorders.