23133-37-1

Basic information

• Product Name: 1-Propyl-4-piperidone
• Synonyms: 1-Propyl-4-piperidinone;4-Piperidinone, 1-propyl-;1-PROPYLPIPERIDIN-4-ONE;1-PROPYL-4-PIPERIDONE;N-PROPYL-4-PIPERIDONE;N-Propyl-4-peperidone;1.46-1.462;1-PROPYL-4-PIPERIDONE 98%
• CAS NO: 23133-37-1
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.21
• EINECS: 245-444-8
• Product Categories: Amines;blocks;Building Blocks;Heterocyclic Building Blocks;Piperidones
• Mol File: 23133-37-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 56 °C1 mm Hg(lit.)
• Flash Point: 168 °F
• Appearance: Clear yellow liquid
• Density: 0.936 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.109mmHg at 25°C
• Refractive Index: n20/D 1.461(lit.)
• Storage Temp.: 0-6°C
• PKA: 8.10±0.20(Predicted)
• CAS DataBase Reference: 1-Propyl-4-piperidone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propyl-4-piperidone(23133-37-1)
• EPA Substance Registry System: 1-Propyl-4-piperidone(23133-37-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• Hazardous Substances Data: 23133-37-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear yellow liquid

Uses

1-Propyl-4-piperidone has been used in the preparation of 9-[2-(2-methyl-5-pyridyl)-ethyl]-3-propyl-1,2,3,4-tetrahydro-γ-carboline1.

InChI:InChI=1/C8H15NO/c1-2-5-9-6-3-8(10)4-7-9/h2-7H2,1H3/p+1

Upstream product

• 41661-47-6 piperidin-4-one 
• 107-08-4 1-iodo-propane 
• 41979-39-9 4-piperidone hydrochloride 
• 106-94-5 propyl bromide 

Downstream Products

• 72808-65-2 5-methoxy-3-(1-propyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole 
• 1566527-90-9 8-chloro-5-(3-(4-chlorophenoxy)propyl)-2-propyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 

Relevant articles and documents

Effect of cathepsin K inhibitors on bone resorption

On the basis of the pyrrolopyrimidine core structure that was previously discovered, cathepsin K inhibitors having a spiro amine at the P3 have been explored to enhance the target, bone marrow, tissue distribution. Several spiro structures were identified with improved distribution toward bone marrow. The representative inhibitor 7 of this series revealed in vivo reduction in C-terminal telopeptide of type I collagen in rats and monkeys.

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

We previously discovered and validated a class of piperidinyl ureas that regulate defective in cullin neddylation 1 (DCN1)-dependent neddylation of cullins. Here, we report preliminary structure-activity relationship studies aimed at advancing our high-throughput screen hit into a tractable tool compound for dissecting the effects of acute DCN1-UBE2M inhibition on the NEDD8/cullin pathway. Structure-enabled optimization led to a 100-fold increase in biochemical potency and modestly increased solubility and permeability as compared to our initial hit. The optimized compounds inhibit the DCN1-UBE2M protein-protein interaction in our TR-FRET binding assay and inhibit cullin neddylation in our pulse-chase NEDD8 transfer assay. The optimized compounds bind to DCN1 and selectively reduce steady-state levels of neddylated CUL1 and CUL3 in a squamous cell carcinoma cell line. Ultimately, we anticipate that these studies will identify early lead compounds for clinical development for the treatment of lung squamous cell carcinomas and other cancers.

Lightening Agents and/or Dyes that Contain Aldehyde(s)

Agents for dyeing and/or lightening keratin fibers, in particular human hair, containing, relative to the weight thereof, 0.001 to 15 wt. % of at least one aldehyde of the formula (I): wherein X represents —CH(R2)—SO2—Y—R1, —CR3R4R5, or wherein Y represents —CH(CHO)— or —CH2— or a chemical bond, and wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 independently represents —H or —CN or —F or —Cl or —Br or —I or —CHO or —NH2 or —NO2 or —CF3 or —CCl3 or —CF2CF3 or —CCl2CCl3 or an optionally substituted (C1-C6) alkyl group or a hydroxyalkyl group or a polyhydroxyalkyl group or an optionally substituted (C1-C6) alkylene group, and wherein the agent contains no oxidation dye precursors of developer and coupler type.