2328-13-4Relevant articles and documents
Peracetylation of polyphenols under rapid and mild reaction conditions
Castro, Rosane Nora,Freire de Lima, Marco Edilson,Pitasse-Santos, Paulo,de Alcantara Pinto, Douglas Chaves,de Souza, Gabriela Alves
supporting information, (2022/01/31)
Structural modifications are an important tool for studying the properties of naturally occurring polyphenols. Regarding the preparation of acetyl esters, the presence of hydroxyl groups stabilized by intramolecular hydrogen bonds may pose an obstacle for
Synthesis of new glycosylated flavonoids with inhibitory activity on cell growth
Neves, Ana R,Correia-da-Silva, Marta,Silva, Patrícia M. A,Ribeiro, Diana,Sousa, Emília,Bousbaa, Hassan,Pinto, Madalena
, (2018/05/22)
Natural flavonoids and xanthone glycosides display several biological activities, with the glycoside moiety playing an important role in the mechanism of action of these metabolites. Herein, to give further insights into the inhibitory activity on cell gr
Regioselective iodination of flavonoids by N-iodosuccinimide under neutral conditions
Lu, Kui,Chu, Jie,Wang, Haomeng,Fu, Xiaoli,Quan, Dewu,Ding, Hongxia,Yao, Qingwei,Yu, Peng
supporting information, p. 6345 - 6348 (2013/11/06)
Regioselective synthesis of C-6 and C-8 monoiodo flavonoids, which are important intermediates for the synthesis of flavonoid natural products and drug molecules, was achieved by iodination of suitably alkylated flavonoids with N-iodosuccinimide (NIS) in DMF. The iodination gives either a C-6 or C-8 iodo flavonoid in high yield, depending on the protection pattern of the C-5 and C-7 OH groups. The mild and neutral conditions render this novel protocol particularly useful for the regioselective iodination of acid-sensitive substrates.