23304-25-8Relevant articles and documents
Continuous Flow Synthesis and Purification of Aryldiazomethanes through Hydrazone Fragmentation
Lévesque, éric,Laporte, Simon T.,Charette, André B.
, p. 837 - 841 (2017/01/14)
Electron-rich diazo compounds, such as aryldiazomethanes, are powerful reagents for the synthesis of complex structures, but the risks associated with their toxicity and instability often limit their use. Flow chemistry techniques make these issues avoidable, as the hazardous intermediate can be used as it is produced, avoiding accumulation and handling. Unfortunately, the produced stream is often contaminated with other reagents and by-products, making it incompatible with many applications, especially in catalysis. Herein is reported a metal-free continuous flow method for the production of aryldiazomethane solutions in a non-coordinating solvent from easily prepared, bench-stable sulfonylhydrazones. All by-products are removed by an in-line aqueous wash, leaving a clean, base-free diazo stream. Three successful sensitive metal-catalyzed transformations demonstrated the value of the method.
A facile one pot synthesis of substituted pyrazole derivatives
Haouas, Amel,Hamadi, Naoufel Ben,Nsira, Asma,Msadek, Moncef
, p. 435 - 437 (2013/09/12)
Diazo compounds derived from aromatic aldehydes were reacted with derivatives of (Z)-2-arylidene-2H-benzofuran- 3-ones to give new highly substituted heterocyclic pyrazoles. The structures of the synthesised compounds were determined on the basis of their
Catalytic homologation of cycloalkanones with substituted diazomethanes.mild and efficient single-step access to α-tertiary and α-q uaternary carbonyl compounds
Moebius, David C.,Kingsbury, Jason S.
supporting information; experimental part, p. 878 - 879 (2009/06/20)
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