23416-69-5

Basic information

• Product Name: 2-Propenoyl chloride, 3-(3,4-dihydroxyphenyl)-
• Synonyms: 2-Propenoyl chloride, 3-(3,4-dihydroxyphenyl)-
• CAS NO: 23416-69-5
• Molecular Formula: C₉H₇ClO₃
• Molecular Weight: 198.60308
• Mol File: 23416-69-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoyl chloride, 3-(3,4-dihydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoyl chloride, 3-(3,4-dihydroxyphenyl)-(23416-69-5)
• EPA Substance Registry System: 2-Propenoyl chloride, 3-(3,4-dihydroxyphenyl)-(23416-69-5)

Safety Data

• Hazardous Substances Data: 23416-69-5(Hazardous Substances Data)

Upstream product

• 331-39-5 caffeic acid 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Downstream Products

• 169232-15-9 3-phenylpropyl 3-(3,4-dihydroxyphenyl)acrylate 
• 115610-24-7 phenylmethyl 1-(3’,4’-dihydroxyphenyl)propenate 
• 73692-51-0 2',3,4,4',6'-pentahydroxychalcone 
• 480-18-2 taxifolin 

Relevant articles and documents

Immobilization of caffeic acid on a polypropylene film: Synthesis and antioxidant properties

The immobilization of caffeic acid (CA) on a polypropylene (PP) film was successfully performed through the covalent binding of the caffeoyl chloride on a modified polymeric surface of PP films grafted with hydroxyethyl methacrylate as monomer (PP-g-HEMA)

A method for preparing coffee acid benzyl ester

The invention discloses a coffee acid benzyl ester of preparation method, the overall steps are: a, the caffeic acid dissolved in organic solvent, the reaction is carried out by adding thionyl chloride, make intermediate A; b, alkali and the presence of o

Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases

The present study reports the synthesis of cinnamide derivatives and their biological activity as inhibitors of both cholinesterases and anticancer agents. Controlled inhibition of brain acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) may slow neurodegeneration in Alzheimer's diseases (AD). The anticholinesterase activity of phenylcinnamide derivatives was determined against Electric Eel acetylcholinesterase (EeAChE) and horse serum butyrylcholinesterase (hBChE) and some of the compounds appeared as moderately potent inhibitors of EeAChE and hBChE. The compound 3-(2-(Benzyloxy)phenyl)-N- (3,4,5-trimethoxyphenyl)acrylamide (3i) showed maximum activity against EeAChE with an IC50 0.29 ± 0.21 μM whereas 3-(2-chloro-6- nitrophenyl)-N-(3,4,5-trimethoxyphenyl)acrylamide (3k) was proved to be the most potent inhibitor of hBChE having IC50 1.18 ± 1.31 μM. To better understand the enzyme-inhibitor interaction of the most active compounds toward cholinesterases, molecular modelling studies were carried out on high-resolution crystallographic structures. The anticancer effects of synthesized compounds were also evaluated against cancer cell line (lung carcinoma). The compounds may be useful leads for the design of a new class of anticancer drugs for the treatment of cancer and cholinesterase inhibitors for Alzheimer's disease (AD).