23431-48-3

Basic information

• Product Name: ALLYL P-TOLYL ETHER
• Synonyms: 4-Allyloxytoluene,Allyl p-Tolyl Ether;Allyl p-Tolyl Ether;ALLYL P-TOLYL ETHER;4-ALLYLOXYTOLUENE;allyltolylether;ally cresyl ether;p-Tolyl allyl ether
• CAS NO: 23431-48-3
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• Mol File: 23431-48-3.mol
• Article Data: 52

Chemical Properties

• Boiling Point: 214.5°C (estimate)
• Flash Point: 79.7 °C
• Appearance: /
• Density: 0.9719
• Vapor Pressure: 4.71E-08mmHg at 25°C
• Refractive Index: 1.5180-1.5200
• CAS DataBase Reference: ALLYL P-TOLYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: ALLYL P-TOLYL ETHER(23431-48-3)
• EPA Substance Registry System: ALLYL P-TOLYL ETHER(23431-48-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 23431-48-3(Hazardous Substances Data)

Usage

General Description

Allyl p-tolyl ether, also known as allyl phenyl ether, is an organic compound with the chemical formula C10H12O. It is a clear, colorless liquid with a strong, sweet odor, and it is insoluble in water but soluble in organic solvents. Allyl p-tolyl ether is commonly used as a fragrance ingredient in perfumes and personal care products. It is also utilized in the manufacturing of pharmaceuticals, dyes, and other specialty chemicals. Additionally, it is a valuable intermediate in organic synthesis, serving as a precursor to various compounds such as allyl phenol and allyl diphenyl ether. However, allyl p-tolyl ether should be handled with caution as it is flammable and may cause irritation to the skin, eyes, and respiratory system upon exposure.

InChI:InChI=1/C16H18O4S/c1-3-7-13-10-11-14(19-2)12-16(13)20-21(17,18)15-8-5-4-6-9-15/h4-6,8-12H,3,7H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 1121-70-6 sodium 4-methylphenoxide 
• 106-95-6 allyl bromide 
• 106-44-5 p-cresol 
• 71-43-2 benzene 
• 420-12-2 thirane 
• 107-05-1 3-chloroprop-1-ene 
• 5954-75-6 2-vinylthiirane 
• 107-18-6 allyl alcohol 
• 67-64-1 acetone 
• 51896-41-4 cis-4-methylphenyl 1-propenyl ether 
• 591-87-7 Allyl acetate 
• 106-38-7 para-bromotoluene 
• 35466-83-2 allyl methyl carbonate 

Downstream Products

• 2186-24-5 cresyl-glicidyl ether 
• 6628-06-4 2-allyl-4-methylphenol 
• 28229-60-9 Dichloro-methyl-(3-p-tolyloxy-propyl)-silane 
• 3199-35-7 2,5-dimethyl-2,3-dihydrobenzo[b]furan 
• 106-44-5 p-cresol 
• 80448-06-2 1-(diethylamino)-2-acetoxy-3-(4-methylphenoxy)propane 
• 61103-67-1 1,2,3,4,7,7-Hexachloro-5-p-tolyloxymethyl-bicyclo[2.2.1]hept-2-ene 
• 51896-41-4 cis-4-methylphenyl 1-propenyl ether 
• 41516-23-8 3-allyl-4-methylphenol 
• 26509-47-7 2,6-diallyl-4-methylphenol 
• 1610349-80-8 (E)-2-[3-(4-methylphenoxy)-1-propen-1-yl]thiophene 
• 1610349-84-2 (E)-1-[3-(4-methylphenoxy)-2-propen-1-yl]naphthalene 
• 55630-71-2 (E)-1-(4''-methylphenyloxy)-3-phenyl-2-propene 
• 74455-33-7 5-methyl-2-(phenylthiomethyl)-2,3-dihydrobenzofuran 

Relevant articles and documents

An SN1-type Reaction to Form the 1,2-Dioxepane Ring: Synthesis of 10,12-Peroxycalamenene

The synthesis of the sesquiterpene endoperoxide natural product 10,12-peroxycalamenene has been achieved. Featured transformations include an intramolecular Heck reaction to build the fused bicyclic core and a cobalt-catalyzed peroxidation to install the peroxide functional group. The final step involved an SN1-type ring closure catalyzed by DDQ to construct the 1,2-dioxepane ring.

Preparation method 3 - phenoxybromopropane or analogue thereof

The invention discloses a preparation method of 3 -phenoxybromopropane or an analogue thereof, wherein 3 - phenoxybromopropane and an allyl compound thereof are obtained through substitution reaction and addition reaction so as to avoid the inconvenience of using gaseous hydrogen bromide, 2nd-step addition reaction is realized by using the brominated salt and the acid in situ, and the process is simple in operation. The condition is easy to control, the atom economy is good, the aspect of environmental impact is low pollution, zero emission accords with the current green chemical synthesis direction, and the cost is economic.

Enantioselective synthesis of 1-aminoindene derivativesviaasymmetric Br?nsted acid catalysis

We describe a catalytic asymmetric iminium ion cyclization reaction of simple 2-alkenylbenzaldimines using a BINOL-derived chiralN-triflyl phosphoramide. The corresponding 1-aminoindenes and tetracyclic 1-aminoindanes are formed in good yields and high enantioselectivities. Further, the chemical utility of the obtained enantiopure 1-aminoindene is demonstrated for the asymmetric synthesis of (S)-rasagiline.

Novel potent vasodilating agents: Evaluation of the activity and potency of LINS01005 and derivatives in rat aorta

Cardiovascular diseases (CVDs) present high prevalence rates in the current world. It is estimated that approximately one-third of the global deaths are related to CVDs, and thus there is still a need for novel drugs to treat these disorders. We serendipitously discovered that LINS01005 (5a) is a potent vasodilating agent in rat aorta, and therefore a set of analogues were evaluated for the vasodilating potency in Wistar and SHR rat thoracic aorta precontracted with norepinephrine, with endothelium intact (E+) or denuded (E–) aortic rings. Compounds 5a and 5b were the most potent, showing submicromolar potency for endothelium intact vessels (EC50 853 and 941 nM, respectively) and micromolar values for E– vessels (EC50 2.4 and 7.1 μM, respectively). These compounds were indeed significantly more potent vasodilating agents in SHR-derived aortic rings (p 50 2.4 nM (E+) 9.0 nM (E–)] and 5b [EC50 20 nM (E+) 2.1 μM (E–)]. SAR analysis though PCA and HCA were performed, suggesting that N-phenylpiperazine is essential to the activity, while increasing volume in the substituted aromatic moiety is detrimental to the potency. This is the first report of the vasodilating properties of such compounds, and studies regarding the mechanism of action are in progress in our group.