2350-51-8Relevant articles and documents
A novel formamidine linker for use in solid-phase synthesis
Furth, Paul S.,Reitman, Michael S.,Cook, Alan F.
, p. 5403 - 5406 (1997)
A variety amidines have been evaluated as linkers for solid-supported synthesis. As a demonstration of its utility, an amidine linker was used to prepare a set of compounds involving amine exchange, oxidation, reduction and ether formation reactions. These compounds were successfully cleaved from the support to generate α-substituted, secondary amine derivatives, which were thoroughly characterized by spectroscopic methods.