235780-25-3

Basic information

• Product Name: 2-Methyl-α-(trifluoromethyl)styrene
• Synonyms: 2-Methyl-α-(trifluoromethyl)styrene
• CAS NO: 235780-25-3
• Molecular Weight: 186.177
• Mol File: 235780-25-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Methyl-α-(trifluoromethyl)styrene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-α-(trifluoromethyl)styrene(235780-25-3)
• EPA Substance Registry System: 2-Methyl-α-(trifluoromethyl)styrene(235780-25-3)

Safety Data

• Hazardous Substances Data: 235780-25-3(Hazardous Substances Data)

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 16419-60-6 2-Methylphenylboronic acid 
• 431-21-0 1,2-Dibromo-3,3,3-trifluoropropane 

Relevant articles and documents

Transition-Metal-Free Defluorosilylation of Fluoroalkenes with Silylboronates

Silylated fluoroalkenes are important synthetic intermediates with complementary reactivity, which play a key role in the construction of natural products, pharmaceuticals, and manmade materials. Converting the normally highly stable fluoroalkenes into si

A novel and convenient synthetic method for producing α-(trifluoromethyl)styrenes (3)

The Suzuki-type coupling reaction of arylboronic acids (1) with 2-bromo-3,3,3-trifluoropropene (2) in the presence of a catalytic amount of dichlorobis(triphenylphosphine)palladium {PdCl2(PPh3)2} and a base can easily give α-(trifluoromethyl)styrenes (3) in good yields. It was also found that 1,2-dibromo-3,3,3-trifluoropropane (4) underwent dehydrobromination in the presence of KOH, and subsequently, palladium-catalyzed cross-coupling with 1 to directly afford 3 in a one pot manner in excellent yields.