23597-82-2

Basic information

• Product Name: Hexyl nicotinoate
• Synonyms: 3-Pyridinecarboxylic acid, hexyl ester;3-pyridinecarboxylicacid,hexylester;Nicotherm;N-HEXYL NICOTINATE;n-Hexyl nicotinoate;NICOTINIC ACID N-HEXYL ESTER;NICOTINIC ACID HEXYL ESTER;HEXYL PYRIDINE-3-CARBOXYLATE
• CAS NO: 23597-82-2
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• EINECS: 245-767-4
• Mol File: 23597-82-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 140°C
• Flash Point: 127.8 °C
• Appearance: /
• Density: 1,02 g/cm3
• Vapor Pressure: 0.000181mmHg at 25°C
• Refractive Index: 1.4880 to 1.4920
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.21±0.10(Predicted)
• Water Solubility: 0.17g/L(32 oC)
• CAS DataBase Reference: Hexyl nicotinoate(CAS DataBase Reference)
• NIST Chemistry Reference: Hexyl nicotinoate(23597-82-2)
• EPA Substance Registry System: Hexyl nicotinoate(23597-82-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 23597-82-2(Hazardous Substances Data)

Usage

Description

Hexyl Nicotinate is an active substance from the group of rubefacients that stimulates blood circulation. It is used for topical treatment of muscle, joint and ligament pain. Hexyl Nicotinate can be used in creams, baths and emulsions, in veterinary as well as in human medicines.

Uses

Different sources of media describe the Uses of 23597-82-2 differently. You can refer to the following data:
1. hexyl nicotinate penetrates rapidly and dilates blood vessels, thereby temporarily activating blood circulation. This increased blood flow results in an enhanced supply of oxygen, nutrients, and moisture to the skin cells, along with a faster elimination of wastes by means of the metabolic process.
2. Hexyl Nicotinoate is a nicotinic acid ester prodrug.

Application

Hexyl Nicotinate is used as a cosmetic ingredient in several applications such as Sun tanning lotion, creams, slimming gels, and creams. It is preferred over Niacin due to its better penetrating power.1.Used in hair loss creams and lotions as vasodilator.2.Ingradient of Transvasin heat rub cream. (Thornton & Ross)3.Used in almost all slimming and tanning cosmetic formulations.

benefits

1. Preferred over Niacin due to its better penetrating power.2. Hexyl Nicotinate demonstrates better rubefacient properties which can produce pronounced thermo-slimming compositions.3. Hexyl Nicotinate enhances blood circulation in the skin and enhances the skin's metabolism.

InChI:InChI=1/C12H17NO2/c1-2-3-4-5-9-15-12(14)11-7-6-8-13-10-11/h6-8,10H,2-5,9H2,1H3

Upstream product

• 59-67-6 nicotinic acid 
• 111-27-3 hexan-1-ol 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 490-11-9 3,4-pyridinecarboxylic acid 

Relevant articles and documents

Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.