2362-79-0

Basic information

• Product Name: 1-(4-chlorophenyl)-N-phenyl-methanimine
• Synonyms: 1-(4-chlorophenyl)-N-phenyl-methanimine;Levocetrizine AMine IMpurity
• CAS NO: 2362-79-0
• Molecular Formula: C₁₃H₁₀ClN
• Molecular Weight: 215.68
• Mol File: 2362-79-0.mol
• Article Data: 197

Chemical Properties

• Boiling Point: 327°Cat760mmHg
• Flash Point: 151.6°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 0.000396mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 1-(4-chlorophenyl)-N-phenyl-methanimine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-N-phenyl-methanimine(2362-79-0)
• EPA Substance Registry System: 1-(4-chlorophenyl)-N-phenyl-methanimine(2362-79-0)

Safety Data

• Hazardous Substances Data: 2362-79-0(Hazardous Substances Data)

Usage

Description

1-(4-chlorophenyl)-N-phenyl-methanimine, commonly known as para-chloroamphetamine, is a chemical compound with the molecular formula C13H11ClN. It is a substituted phenethylamine and belongs to the class of amphetamines. 1-(4-chlorophenyl)-N-phenyl-methanimine is an analog of the psychoactive drug amphetamine and is known for its stimulant and hallucinogenic effects. It acts as a releasing agent for serotonin, norepinephrine, and dopamine in the brain, which has led to its study for potential use in treating various medical conditions such as depression and obesity.

Uses

Used in Pharmaceutical Research:
1-(4-chlorophenyl)-N-phenyl-methanimine is used as a research compound for its potential therapeutic applications in the treatment of medical conditions like depression and obesity. Its action as a releasing agent for serotonin, norepinephrine, and dopamine makes it a subject of interest for scientists exploring novel treatments for these conditions.
Used in Psychopharmacology:
In the field of psychopharmacology, 1-(4-chlorophenyl)-N-phenyl-methanimine is used as a research tool to study the effects of stimulants and hallucinogens on the brain's neurotransmitter systems. Understanding its mechanism of action can contribute to the development of new drugs with fewer side effects and lower potential for abuse.
Used in Controlled Substance Regulation:
Due to its stimulant and hallucinogenic properties, 1-(4-chlorophenyl)-N-phenyl-methanimine is considered a controlled substance in many countries. It is used in the regulatory industry to develop and enforce policies and laws related to the control and prevention of substance abuse and addiction.

InChI:InChI=1/C13H10ClN/c14-12-8-6-11(7-9-12)10-15-13-4-2-1-3-5-13/h1-10H/b15-10+

Upstream product

• 37613-10-8 4-chloro-N-phenyl-benzimidoyl chloride 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 104478-87-7 5-(p-chlorophenyl)-3-(p-methoxyphenyl)-4-phenyl-4,5-dihydro-1,2,4-thiadiazole 
• 5909-74-0 (4-chlorobenzylidene)phenylamine N-oxide 
• 2998-98-3 (Z)-(4-chlorophenyl)(phenyl)methanone oxime 
• 62-53-3 aniline 
• 873-76-7 para-Chlorobenzyl alcohol 
• 589-18-4 4-Methylbenzyl alcohol 
• 100-51-6 benzyl alcohol 
• 104-88-1 4-chlorobenzaldehyde 
• 98-95-3 nitrobenzene 
• 857402-61-0 N-(pinacolboryl)aniline 
• 100-52-7 benzaldehyde 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 225506-79-6 4-methyl-2-<1-(4-chlorophenyl)-1-(phenylamino)-methyl>-3-morpholinone 
• 4322-59-2 3,3'-(4-chlorophenylmethylene)-bis-4-hydroxycoumarin 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 91462-59-8 dimethyl 2-(4-chlorophenyl)-1-phenyl-1H-pyrrole-3,4-dicarboxylate 
• 178946-89-9 bis(3-indolyl)-4-chlorophenylmethane 
• 1131377-07-5 2-(4-chlorophenyl)-4-di(4-methylphenyl)methylene-3-diphenylmethylene-1-phenylpyrrolidine 
• 1131377-22-4 2-(4-chlorophenyl)-4-di(4-methylphenyl)methylene-1-phenyl-3-[(E)-1-phenylethylidene]pyrrolidine 
• 1131377-01-9 2-(4-chlorophenyl)-3,4-bis(diphenylmethylene)-1-phenylpyrrolidine 

Relevant articles and documents

Experimental and theoretical investigation of benzyl-N-pyrrolylketene, one- step procedure for preparing of new β-lactams by [2 +2] cycloaddition reaction

3-Phenyl-2-(1-H-pyrrol-1-yl) propanoic acid has been used as a ketene source in synthesizing of monocyclic-2-azetidinones. Hindrance in ketene and imines successfully controlled the diastereoselectivity of the reaction. For example, in some cases only one isomer was achieved. By using Mukaiyama reagent, the leaving group in acid was activated and the by-products were separated by simple aqueous work-up. DFT calculation indicated that the benzyl-N-pyrrolylketene has nonconjugated structure and the pyrrolyl ring is perpendicular to the ketene plane in both the twisted and planar structures.

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.

Visible-Light-Induced Cycloaddition of α-Ketoacylsilanes with Imines: Facile Access to β-Lactams

We report the synthesis of β-lactams from α-ketoacylsilanes and imines, which proceeds via a formal [2+2] photochemical cycloaddition with in situ generation of siloxyketene. This mild and operationally simple reaction proceeds in an atom-economic fashion with broad substrate scope, including aldimines, ketimines, hydrazones, and fused nitrogen heterocycles, affording a variety of important β-lactams with satisfactory diastereoselectivities in most cases. This reaction also features good functional-group tolerance, facile scalability and product diversification. Experimental and computational studies suggest that α-ketoacylsilanes can serve as photochemical precursors by engaging in a 1,3 silicon shift to the distal carbonyl group.