23713-85-1Relevant articles and documents
Thermal Stimuli-Triggered Drug Release from a Biocompatible Porous Metal–Organic Framework
Jiang, Ke,Zhang, Ling,Hu, Quan,Zhang, Qi,Lin, Wenxin,Cui, Yuanjing,Yang, Yu,Qian, Guodong
, p. 10215 - 10221 (2017)
Drug delivery carriers with a high drug loading capacity and biocompatibility, especially for controlled drug release, are urgently needed due to the side effects and frequently dose in the traditional therapeutic method. In our work, a Zr-based metal–organic framework named ZJU-801, which is isoreticular with NU-801, has been designed and further demonstrated as an excellent drug delivery system (DDS) with a high drug loading of 41.7 %. Such a high drug loading capacity may be ascribed to the appropriate match of the size and the large pore volume of this kind of Zr MOF material. Compared with DS@NU-801, this DDS has successfully achieved on-command heating-activated drug release, which was probably attributed to the bulkier ligand, the better stability, and the intense π–π interaction between ZJU-801 and diclofenac sodium (DS) demonstrated comprehensively by SEM, powder X-ray diffraction (PXRD), FTIR and 13C solid-state NMR spectroscopy as well as computer simulations. It is worth noting that premature drug release was avoided effectively without any complicated post-modifications. The low cytotoxicity and good biocompatibility of our DDS were certificated by the in vitro favorable results from an MTT assay, a WST-1 assay, and confocal microscopy imaging.
Synthesis, photophysics, and electroluminescence of conjugated poly(p-phenylenevinylene) derivatives with 1,3,4-oxadiazoles in the backbone
Mikroyannidis, John A.,Spiliopoulos, Ioakim K.,Kasimis, Theodoros S.,Kulkarni, Abhishek P.,Jenekhe, Samson A.
, p. 9295 - 9302 (2007/10/03)
Starting from 4-bromobenzaldehyde or 1,4-benzenedicarboxaldehyde, two new poly(p-phenylenevinylene) derivatives P1 and P2 were synthesized by a five-step synthetic route. These fully conjugated polymers contain 1 or 2 oxadiazole rings and 3 or 4 vinylene bonds per repeat unit for P1 and P2, respectively, and were amorphous and soluble in common organic solvents. The Tg values were 28°C for P1 and 57°C for P2. The polymers emitted greenish-blue light in solution with photoluminescence (PL) emission maximum at 487-511 nm and yellowish-green light with PL emission maximum at 515-558 nm in thin films. Electroluminescence (EL) was achieved from single-layer LEDs of polymer P1 with the configuration ITO/PEDOT/P1/Al with voltage-tunable EL colors from 558 nm (9 V) to 527 nm (16 V). The observed EL spectral blue shift with increasing voltage is a result of conformational changes of the polymer backbone with increase in temperature, as evidenced from the absorption and PL spectra changes upon annealing of P1 thin films at different temperatures.
Acrylamide derivatives and process for production thereof
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, (2008/06/13)
Acrylamide derivatives represented by General Formula (1) below: STR1 (One specific example of General Formula (1) is methyl (S,S)-3,3'-?3,3'-(1,4-phenylenediacryloyl)!-bis?1-chloromethyl-5-hydroxy-7-triflouromethyl-1, 2,3,6-tetrahydropyrrolo?3,2-e!indole-8-carboxylate.) The acrylamide derivatives represented by General Formula (1) is highly selective to cancer cells, less toxic, and highly active also against solid tumor.
