2372-45-4Relevant articles and documents
USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS
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Page/Page column 13, (2010/11/26)
Compounds of the formula and pharmaceutically acceptable salts thereof for use as inhibitors of cyclin dependent kinases, wherein: X is O, S(O)m; Y is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl; R1 is hydrogen or lower alkyl; R2 is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -O-alkyl, -O-aryl, -NR4R5; R3 is hydrogen or lower alkyl; R4 is hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -O-alkyl, -O-aryl; R5 is hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, cycloalkyl, alkylcycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, -O-alkyl, -O-aryl; and m is 0, 1 or 2. The compounds of formula I are protein kinase inhibitors and are useful in the treatment and prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's disease, cardiovascular diseases, viral diseases and fungal diseases.
PYRAZOLOPYRIMIDINE AND PYRAZOLOTRIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 91-92, (2010/02/07)
The present invention provides compounds of formula (I), pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. For the prophylaxis or treatment of a condition or disease associated with a herpes viral infection.
Benzylidene-camphors, processes for their preparation and cosmetic compositions containing them
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, (2008/06/13)
The invention provides compounds which are particularly valuable for use as the active ingredient in sun tan lotions and creams and the like. These compounds have the general formula: STR1 in which Y denotes hydrogen or the radical SO3 H or a salt thereof with an organic or inorganic base, and Z denotes the radical --CH2 Br or --CHBrBr or a radical Z' which denotes the radical --CH2 I, --CH2 R, --CHR'R', --CHO or --COOR", in which R denotes --NR1 R2, --N+ R1 R2 R3, --OR4, --OCOR5, --SR6, --CN, -COOR" or --SSO3 Na, in which R1 and R2 independently denote hydrogen, C1-18 alkyl or hydroxyalkyl, or R1 and R2, together with the nitrogen atom to which they are attached, denote a heterocyclic ring, R3 denotes C1-4 alkyl or hydroxyalkyl or sulphonatopropyl, R4 denotes hydrogen, alkyl, polyoxyethylene, aryl which is optionally substituted, menthyl or dialkylaminoalkyl, R5 denotes alkyl, alkenyl, aryl or a 5 or 6 membered heterocyclic ring which is optionally aromatic, and R6 denotes hydrogen, alkyl, carboxyalkyl, aminoalkyl, hydroxyalkyl, aryl or 3-alanyl, R' denotes --OR'4 or --SR'6, in which R'4 and R'6 are as defined under R4 and R6, respectively, except for hydrogen, polyoxyethylene, hydroxyalkyl, 3-alanyl and aryl, and R" denotes hydrogen or alkyl, such that when R denotes N+ R1 R2 R3, R1 and R2 are not hydrogen and either R3 denotes sulphonatopropyl, or the compound is in the form of a salt with an anion, which is SO4 alkyl, SO3 aryl, SO3 alkyl or halogen or an inorganic or organic acid addition salt thereof when R denotes --NR1 R2.
