23815-28-3

Basic information

• Product Name: 3,4-DICHLOROBENZENESULFONAMIDE
• Synonyms: Nsc31188
• CAS NO: 23815-28-3
• Molecular Formula: C₆H₅Cl₂NO₂S
• Molecular Weight: 226.08
• Mol File: 23815-28-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 137-139°C
• Boiling Point: 383.4 °C at 760 mmHg
• Flash Point: 185.7 °C
• Appearance: /
• Density: 1.4399 (rough estimate)
• Vapor Pressure: 4.39E-06mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• PKA: 9.62±0.60(Predicted)
• Water Solubility: 791.3mg/L(15 oC)
• CAS DataBase Reference: 3,4-DICHLOROBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLOROBENZENESULFONAMIDE(23815-28-3)
• EPA Substance Registry System: 3,4-DICHLOROBENZENESULFONAMIDE(23815-28-3)

Safety Data

• Hazardous Substances Data: 23815-28-3(Hazardous Substances Data)

Usage

Uses

3,4-Dichlorobenzenesulfonamide can be used as sulfoamide carbonic anhydrase inhibitors.

InChI:InChI=1/C6H5Cl2NO2S/c7-5-2-1-4(3-6(5)8)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 5858-17-3 3,4-dichlorothiophenol 
• 18282-59-2 4-bromo-1,2-dichlorobenzene 
• 473935-61-4 C₁₂H₈Cl₈N₂O₆S 
• 98-31-7 3,4-dichlorobenzenesulphonyl chloride 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 109014-62-2 bis-(3,4-dichloro-benzenesulfonyl)-amine 
• 82968-07-8 (3,4-dichloro-benzenesulfonyl)-propionyl-amine 
• 33013-84-2 (3,4-dichloro-benzenesulfonyl)-carbamic acid ethyl ester 
• 102607-85-2 3,4-Dichloro-N-([(4-trifluoromethylphenyl)-amino]carbonyl)benzenesulfonamide 
• 1057257-34-7 C₂₈H₂₀Cl₂N₂O₄S 
• 1416326-50-5 C₂₆H₁₇Cl₄FN₂O₄S 
• 1359834-28-8 N-(3-(1H-tetrazol-5-ylthio)-4-hydroxynaphthalen-1-yl)-3,4-dichlorobenzenesulfonamide 
• 1359834-52-8 3,4-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)benzenesulfonamide 
• 93487-83-3 N-(bis-methylsulfanyl-methylidene)-3,4-dichloromethylbenzenesulfonamide 
• 1257328-44-1 C₂₀H₁₇Cl₃N₄O₂S 
• 499152-51-1 N-(3,4-dichlorophenylsulfonyl)-3-(2-(2-(naphthalen-2-yl)ethoxy)-4-(pyrazol-1-ylmethyl)phenyl)propanamide 
• 7062-51-3 3,4-dichlorophenylsulfonylcarbamic acid methyl ester 

Relevant articles and documents

Palladium-Catalyzed ortho-Benzoylation of Sulfonamides through C?H Activation: Expedient Synthesis of Cyclic N-Sulfonyl Ketimines

The ortho-carbonylation of sulfonylarenes by non-hazardous aryl aldehydes as a carbonyl precursor was reported. In this method, the sulfonamide group serves as a directing group for C?H activation in the presence of a Pd catalyst under ligand-free conditions. The scope of this strategy has been extended to the one-pot two-step synthesis of cyclic N-sulfonyl ketimines under mild reaction conditions. Our approach could be considered as an alternative by circumventing the use of highly reactive organolithium or Grignard reagents to access a wide range of biologically potent cyclic N-sulfonyl ketimines. (Figure presented.).

PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

The invention provides compounds of formula (I),wherein R?1?,R?2? ,R?3? and R?4? are as defined in the specification,processes for preparing such compounds,to pharmaceutical compositions comprising such compounds and to the use of the compounds as active

A mild, efficient method for the synthesis of aromatic and aliphatic sulfonamides

A two-step method was developed for the synthesis of aromatic and aliphatic sulfonamides from the corresponding sulfinates using bis(2,2,2-trichloroethyl)azodicarboxylate as the electrophilic nitrogen source. The intermediate sulfonylhydrazides were obtained in very good yields and were cleaved under reductive conditions to deliver the desired sulfonamides. A variety of substituents in the aromatic ring are well tolerated as well as heterocycles.