23891-08-9

Basic information

• Product Name: 6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione
• Synonyms: 1,2,4-Triazine-3,5(2H,4H)-dione, 6-phenyl-; 6-Phenyl-1,2,4-triazine-3,5(2H,4H)-dione
• CAS NO: 23891-08-9
• Molecular Formula: C₉H₇N₃O₂
• Molecular Weight: 189.1708
• Mol File: 23891-08-9.mol
• Article Data: 5

Chemical Properties

• Density: 1.46g/cm³
• Refractive Index: 1.697
• CAS DataBase Reference: 6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione(23891-08-9)
• EPA Substance Registry System: 6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione(23891-08-9)

Safety Data

• Hazardous Substances Data: 23891-08-9(Hazardous Substances Data)

Upstream product

• 38132-38-6 benzoylformic acid semicarbazone 
• 447-00-7 6-phenyl-1,2,4-triazine-3(2H)-thione-5(4H)-one 
• 79-11-8 chloroacetic acid 
• 611-73-4 Benzoylformic acid 
• 98-86-2 acetophenone 

Downstream Products

• 126382-45-4 3,5-Dioxo-6-phenyl-2,5-dihydro-3H-[1,2,4]triazine-4-carboxylic acid dimethylamide 
• 106119-77-1 4-nitroso-6-phenyl-1,2,4-triazine-3,5-dione 
• 861519-05-3 (+/-)-semicarbazido-phenyl-acetic acid 
• 1160976-82-8 1-(indan-2-yloxymethyl)-5-phenyl-6-azauracil 
• 1160976-90-8 1-(2-cyclohexylethoxymethyl)-5-phenyl-6-azauracil 
• 1160976-62-4 1-benzyloxymethyl-5-phenyl-6-azauracil 
• 1160976-66-8 1-allyloxymethyl-5-phenyl-6-azauracil 
• 1160976-52-2 1-methylthiomethyl-5-phenyl-6-azauracil 
• 1160976-84-0 1-(3-cyclohexen-1-ylmethoxymethyl)-5-phenyl-6-azauracil 
• 1160976-56-6 1-ethoxymethyl-5-phenyl-6-azauracil 
• 1160976-58-8 5-benzyl-1-ethoxymethyl-6-azauracil 
• 1160976-72-6 2-{[(2-methylprop-2-en-1-yl)oxy]methyl}-6-phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione 
• 1138419-94-9 2-acetyl-6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione 
• 496913-06-5 {2-[2-(2,6-difluoro-benzyl)-3,5-dioxo-6-phenyl-2,5-dihydro-3H-[1,2,4]triazin-4-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides

The present study describes synthesis and antimicrobial evaluation of a series of novel 6-azauracil non-nucleosides. Reaction of silylated 6-azauracils with the appropriate chloroethers gave the corresponding non-nucleosides. 1-(Allyloxymethy)-6-azauracils and non-nucleosides bearing indanyl, cyclohexenyl, and cyclohexyl moieties were obtained via silylation of 6-azauracils followed by treatment with the appropriate acetals. Selected compounds were tested for their in vitro antimicrobial activity against a panel of standard strains of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Four compounds showed marked inhibitory activity particularly against the tested Gram-positive bacteria.

1,2,4-TRIAZINES DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN HUMAN THERAPEUTICS

The invention relates to 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives of general formulae (I or II), in which in particular: R1 represents hydrogen, a linear or branched C1-C6 alkyl or alkoxy radical, a C5-C6 cycloalkyl radical, a phenyl (C1-C2) alkyl radical or a phenyl radical;-R2 represents hydrogen, a linear or branched Cl-C7alkyl radical, or a C1-C6 alkyl radical substituted with groups such as trifluoromethyl or phenyl;- linker represents a C2-C6 alkyl chain or -(CH2)n-O- (n = 2 to 5), - R3 represents a group of general formula below for which X = O, linker can be connected to the ortho-, meta- or para-positions of the aromatic of the group R3, R4, R5, R6, R7 and R8 represent hydrogen or fluorine, R9, Rio and R11 represent hydrogen or a linear or branched Cl-C5 alkyl group, in particular R9 and Rio represent the methyl group and R11 represents hydrogen or the ethyl group.

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, Rs