23942-99-6

Basic information

• Product Name: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol
• Synonyms: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol;alpha-narcotinediol
• CAS NO: 23942-99-6
• Molecular Formula: C₂₂H₂₇NO₇
• Molecular Weight: 417.45228
• EINECS: 245-946-7
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 23942-99-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130-132 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7))
• Boiling Point: 570.3°Cat760mmHg
• Flash Point: 298.7°C
• Appearance: /
• Density: 1.3g/cm³
• PKA: 13.25±0.20(Predicted)
• CAS DataBase Reference: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol(CAS DataBase Reference)
• NIST Chemistry Reference: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol(23942-99-6)
• EPA Substance Registry System: [S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol(23942-99-6)

Safety Data

• Hazardous Substances Data: 23942-99-6(Hazardous Substances Data)

Usage

Description

[S-(R,S)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol is a complex organic compound with a unique molecular structure. It belongs to the noscapinoid class of microtubule binding compounds, which are known for their ability to alter microtubule dynamics without affecting tubulin polymer mass. [S-(R,S)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol is characterized by its white solid appearance and has potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
[S-(R,S)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol is used as a chemotherapeutic agent for the treatment of human cancers. As a noscapinoid, it shows great promise in this application due to its ability to alter microtubule dynamics, which can lead to the inhibition of cancer cell growth and proliferation.
Used in Drug Delivery Systems:
In the field of drug delivery, [S-(R,S)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol can be employed to improve the delivery, bioavailability, and therapeutic outcomes of various drugs. Its unique chemical properties may allow for the development of novel drug delivery systems, such as organic and metallic nanoparticles, to enhance the efficacy of the compound in treating specific conditions.
Used in Research and Development:
Due to its unique molecular structure and potential applications, [S-(R,S)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol can be used in research and development for the discovery of new drugs and therapies. Its properties may provide valuable insights into the development of novel compounds with similar or improved characteristics for various applications.

Upstream product

• 71-43-2 benzene 
• 128-62-1 noscapine 
• 106982-93-8 (+)-papaveroxinoline 
• 106982-95-0 narcotinediol diacetate 

Downstream Products

• 106982-93-8 (+)-papaveroxinoline 
• 136617-42-0 isopapaveroxinoline 
• 136617-41-9 O-acetylnarcotinediol 7'-silyl ether 
• 42011-37-0 9,10,14-trimethoxy-7ξ-methyl-13c-(toluene-4-sulfonyloxy)-(13ar)-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; chloride 
• 35306-96-8 9,10-dimethoxy-13-methyl-5,13-dihydro-6H,8H-benzo[g][1,3]dioxolo[4',5':7,8]chromeno[3,4,5-ija]quinolizine 
• 87633-33-8 2-(3,4-Dimethoxyphenyl)-3-dimethylamino-6,7-methylendioxy-4-vinyl-dihydrobenzofuran 
• 87633-32-7 2-(3,4-Dimethoxyphenyl)-2a,3,4,5-tetrahydro-3-methyl-7,8-methylendioxy-2H-furo<2,3,4-i,k>isochinolin 
• 10421-76-8 noscapine 
• 136617-40-8 narcotinediol 7'-silyl ether 
• 106982-95-0 narcotinediol diacetate 
• 65620-68-0 (S)-5-(3,4-dimethoxy-2-methyl-benzyl)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 42011-37-0 (13aR)-9,10,14-trimethoxy-7ξ-methyl-13c-(toluene-4-sulfonyloxy)-(13ar)-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; chloride 
• 82-54-2 4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-ol 

Relevant articles and documents

Conversion of hydrastine into berberine, and an instance of the asymmetrical quaternization of a tertiary base.

-

The influence of the alkaloid narcotine and its dioles on the histamine level of the tissue

-