240400-95-7

Basic information

• Product Name: 6-Bromo-1,4-dichlorophtha...
• Synonyms: 6-Bromo-1,4-dichlorophtha...;6-BroMo-1,4-dichlorophthalazine;PHTHALAZINE, 6-BROMO-1,4-DICHLORO
• CAS NO: 240400-95-7
• Molecular Formula: C₈H₃BrCl₂N₂
• Molecular Weight: 277.93282
• Mol File: 240400-95-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 449.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.851±0.06 g/cm3(Predicted)
• PKA: -1.70±0.30(Predicted)
• CAS DataBase Reference: 6-Bromo-1,4-dichlorophtha...(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-1,4-dichlorophtha...(240400-95-7)
• EPA Substance Registry System: 6-Bromo-1,4-dichlorophtha...(240400-95-7)

Safety Data

• Hazardous Substances Data: 240400-95-7(Hazardous Substances Data)

Usage

General Description

6-Bromo-1,4-dichlorophthalazine is a chemical compound that belongs to the class of phthalazines. It is an organic compound with the molecular formula C8H4BrCl2N2O2. 6-Bromo-1,4-dichlorophtha... is a derivative of phthalazine and contains both bromine and chlorine atoms. It is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use as an antibacterial and antifungal agent. Additionally, it has been investigated for its potential use as a precursor in the synthesis of various organic compounds. Due to its chemical composition and properties, 6-Bromo-1,4-dichlorophthalazine is a versatile compound with a variety of potential applications in the field of chemistry and medicine.

Upstream product

• 76240-49-8 6-bromo-2,3-dihydrophthalazine-1,4-dione 
• 240400-94-6 6-bromo-1,4-phthalazinedione 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 86-90-8 4-bromophthalic anhydride 

Downstream Products

• 1028338-57-9 7-bromo-4-chloro-2H-phthalazin-1-one 
• 1028338-59-1 6-bromo-4-chlorophthalazin-1(2H)-one 
• 240400-93-5 6-Bromo-1-chloro-4-[(3-chloro-4-methoxybenzyl)amino]phthalazine 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS AND METHODS

The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

N -Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism

An unprecedented N -chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n -Bu 4NCl as an exogenous nucleophile was identified, and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives. Also, an improvement of overall efficiency was demonstrated by the use of a labile O -silyl group. A bicyclization/ring-opening mechanism, inspired by the Favorskii rearrangement, was proposed and supported by the DFT calculations. Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity is a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.

SOS1 INHIBITORS

The present invention relates to compounds that inhibit Son of sevenless homolog 1 (SOS1) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.