24059-71-0Relevant articles and documents
Conformational Analysis of Rotational Barriers in N-Arylpyrrolidin-2-ones
Billing, D. G.,Boeyens, J. C. A.,Denner, L.,Plooy, K. E. Du,Long, G. C.,Michael, J. P.
, p. 284 - 288 (1991)
The structures of N-phenylpyrrolidin-2-one and the three isomeric N-tolylpyrrolidin-2-ones have been studied by single-crystal X-ray diffraction, as a basis for the conformational analysis of the barrier to rotation around the single bond between the rings.Force-field simulation of the molecular structure is consistent with a rotational barrier of 7 kJ mol-1.Crystal data: N-phenylpyrrolidin-2-one, orthorhombic, Pbca, a = 14.114 (3), b = 6.879 (4), c = 17.386 (5) Angstroem, R = 0.059 for 1110 unique reflections o4?(Fo)>; N-(2-methylphenyl)pyrrolidin-2-one,orthorhombic, Pbca, a = 16.999 (4), b = 16.411 (2), c = 7.008 (2) Angstroem, R = 0.077 for 1479 unique reflections o4?(Fo)>; N-(3-methylphenyl)pyrrolidin-2-one, monoclinic, P21/c, a = 10.411 (2), b = 7.645 (2), c = 12.782 (1) Angstroem, β = 110.32 (1) deg, R = 0.065 for 1641 unique reflections o4?(Fo)>; N-(4-methylphenyl)pyrrolidin-2-one, orthorhombic, P212121, a = 7.668 (2), b = 10.804 (2), c = 11.456 (1) Angstroem, R = 0.054 for 1155 unique reflections o4?(Fo)>.
Novel tertiary sulfonamides as potent anti-cancer agents
Okolotowicz, Karl J.,Dwyer, Mary,Ryan, Daniel,Cheng, Jiongjia,Cashman, Emily A.,Moore, Stephanie,Mercola, Mark,Cashman, John R.
supporting information, p. 4441 - 4451 (2018/08/03)
For adult women in the United States, breast cancer is the most prevalent form of cancer. Compounds that target dysregulated signal transduction can be efficacious anti-cancer therapies. A prominent signaling pathway frequently dysregulated in breast canc
An Annulative Synthetic Strategy for Building Triphenylene Frameworks by Multiple C?H Bond Activations
Mathew, Bijoy P.,Yang, Hyun Ji,Kim, Joohee,Lee, Jae Bin,Kim, Yun-Tae,Lee, Sungmin,Lee, Chang Young,Choe, Wonyoung,Myung, Kyungjae,Park, Jang-Ung,Hong, Sung You
supporting information, p. 5007 - 5011 (2017/04/24)
C?H activation is a versatile tool for appending aryl groups to aromatic systems. However, heavy demands on multiple catalytic cycle operations and site-selectivity have limited its use for graphene segment synthesis. A Pd-catal- yzed one-step synthesis of functionalized triphenylene frameworks is disclosed, which proceeds by 2- or 4-fold C?H arylation of unactivated benzene derivatives. A Pd2(dibenzylideneacetone)3 catalytic system, using cyclic diaryliodonium salts as π-extending agents, leads to site-selective inter- and intramolecular tandem arylation sequences. Moreover, N-substituted triphenylenes are applied to a field-effect transistor sensor for rapid, sensitive, and reversible alcohol vapor detection.