24105-07-5

Basic information

• Product Name: 2-propylcyclopent-2-en-1-one
• CAS NO: 24105-07-5
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.1803
• Mol File: 24105-07-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 198.5°C at 760 mmHg
• Flash Point: 76.6°C
• Density: 0.951g/cm³
• Vapor Pressure: 0.358mmHg at 25°C
• Refractive Index: 1.474
• CAS DataBase Reference: 2-propylcyclopent-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-propylcyclopent-2-en-1-one(24105-07-5)
• EPA Substance Registry System: 2-propylcyclopent-2-en-1-one(24105-07-5)

Safety Data

• Hazardous Substances Data: 24105-07-5(Hazardous Substances Data)

Upstream product

• 16424-53-6 trans-5-octenoic acid 
• 66662-22-4 4-Oxo-octanal 
• 91791-19-4 6-n-propyl-1,4-dioxaspiro<4.4>non-7-ene 
• 57133-52-5 (E)-2-propylidenecyclopentanone 
• 86119-84-8 phosphoric acid 
• 110-93-0 6-Methyl-hept-5-en-2-on 
• 123-72-8 butyraldehyde 
• 120-92-3 cyclopentanone 
• 3008-40-0 cyclopentane-1,2-dione 
• 83125-34-2 6-Methyl-5-hepten-2-one cyclohexylimine 
• 125630-61-7 9-Methyl-dec-8-en-5-one 
• 91791-14-9 6-n-propyl-1,4-dioxa-8-thiaspiro<4.5>decane 8,8-dioxide 
• 91791-12-7 6-allyl-1,4-dioxa-8-thiaspiro<4,5>-decane 8,8-dioxide 
• 91791-07-0 6-Allyl-1,4-dioxa-8-thia-spiro[4.5]decane 

Relevant articles and documents

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Cyclic ketones, their preparation and their use in the synthesis of amino acids

A method is provided for making an enantiomerically pure of the formula: in which R and R′ represent C1?C10 alkyl, C2?C10 alkenyl or C3?C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g. in the case of the acetoxy compound, a trans 3,4-disubstituted addition product of formula III or IV; The acetyl group is eliminated from the addition product to give an (R)- or (S)-4-alkyl or 4-alkenyl cyclopent-2-en-1-one the compound of formula is then to be hydrogenated to give a cyclopentanone of formula (I) or conjugate addition of a second organometallic nucleophile that provides a group R′ as defined above to the compound of the above formula may be carried out to give a trans 3,4-disubstituted addition product of formula (II). One of the above compounds may be converted e.g. via an intermediate (XV)-(XVIII) (in which the substituents R and R′ and the wedges have the meanings indicated above) to a gabapentin analogue of one of the formulae shown below: in which the substituents R and R′ and the wedges also have the meanings indicated above.

Synthesis of 2-Alkyl-2-cyclopenten-1-ones. A Versatile Kinetic Alkylation-Ozonolysis Procedure for the Preparation of γ-Ketoaldehydes

A range of 2-alkyl-2-cyclopenten-1-ones including the prostaglandin precursor 2-(6-methoxycarbonylhexyl)-2-cyclopenten-1-one and the jasmonoid precursor 2--2-cyclopenten-1-one, have been prepared by a short synthetic route which begins with 6-methyl-5-hepten-2-one and generates the key 1,4-ketoaldehyde intermediates by a kinetic alkylation-ozonolysis procedure.