241472-13-9

Basic information

• Product Name: C₇₃H₈₄O₁₂P₂Si
• Synonyms: C₇₃H₈₄O₁₂P₂Si
• CAS NO: 241472-13-9
• Molecular Weight: 1243.5
• Mol File: 241472-13-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₇₃H₈₄O₁₂P₂Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₇₃H₈₄O₁₂P₂Si(241472-13-9)
• EPA Substance Registry System: C₇₃H₈₄O₁₂P₂Si(241472-13-9)

Safety Data

• Hazardous Substances Data: 241472-13-9(Hazardous Substances Data)

Upstream product

• 241472-11-7 tetrabenzyl 2-(4-carboxyphenyl)ethane-1,1-diphosphonate 
• 241472-34-4 tetrabenzyl 2-(4-carbomethoxyphenyl)ethane-1,1-diphosphonate 
• 133918-47-5 tetrabenzyl methylenediphosphonate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 363-24-6 dinoprostone 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 241472-12-8 [1-(bis-benzyloxy-phosphoryl)-2-(4-chlorocarbonyl-phenyl)-ethyl]-phosphonic acid dibenzyl ester 
• 241472-09-3 PGE₂-t-butyl-diphenylsilyl ester 

Downstream Products

• 241472-14-0 4-[2,2-Bis-(bis-benzyloxy-phosphoryl)-ethyl]-benzoic acid (S)-1-{(E)-2-[(1R,2R,5R)-2-((Z)-6-carboxy-hex-2-enyl)-5-hydroxy-3-oxo-cyclopentyl]-vinyl}-hexyl ester 

Relevant articles and documents

Prostaglandin E2-bisphosphonate conjugates: Potential agents for treatment of osteoporosis

Conjugates of bisphosphonates (potential bone resorption inhibitors) and prostaglandin E2 (a bone formation enhancer) were prepared and evaluated for their ability to bind to bone and to liberate, enzymatically, free PGE2. The conjugate 3, an amide at C-1 of PGE2 proved to be too stable in vivo while conjugate 6, a thioester, was too labile. Several PGE2, C-15 ester-linked conjugates (18, 23, 24 and 31) were prepared and conjugate 23 was found to bind effectively to bone in vitro and in vivo and to liberate PGE2 at an acceptable rate. A 4-week study in a rat model of osteoporosis showed that 23 was better tolerated and more effective as a bone growth stimulant than daily maximum tolerated doses of free PGE2. Copyright (C) 1999 Elsevier Science Ltd.