2417-74-5 Usage
Description
4-N-BUTOXYBENZYL BROMIDE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its bromine atom and butoxybenzyl group, which contribute to its reactivity and utility in chemical reactions.
Uses
Used in Pharmaceutical Industry:
4-N-BUTOXYBENZYL BROMIDE is used as a chemical intermediate for the preparation of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines. These compounds exhibit antirhinovirus activity, making them valuable in the development of antiviral medications to combat rhinovirus infections.
Additionally, 4-N-BUTOXYBENZYL BROMIDE is utilized in the synthesis of alkyl derivatives of the glycopeptide antibiotic A40926 and their amides. These derivatives possess antibacterial activity, which is essential in the development of new antibiotics to address the growing concern of antibiotic resistance.
Synthesis
The synthesis of 4-N-BUTOXYBENZYL BROMIDE is as follows:Under the protection of nitrogen,Add 40g of compound 5-1 to a 1L reaction flask,50g hydrogen bromide solution (hydrogen bromide concentration is 40wt%) and 500mL toluene,After fully dissolving, control the temperature between 110130,The reaction was stirred for 5h.Add 300 mL of ethyl acetate and 400 mL of water to the reaction solution for extraction,Collect the ethyl acetate layer, add anhydrous sodium sulfate for drying, then concentrate,Obtain 40 g of white solid (compound 6-1),The yield was 74.12%.
Check Digit Verification of cas no
The CAS Registry Mumber 2417-74-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,1 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2417-74:
(6*2)+(5*4)+(4*1)+(3*7)+(2*7)+(1*4)=75
75 % 10 = 5
So 2417-74-5 is a valid CAS Registry Number.
2417-74-5Relevant articles and documents
Azo dye, and preparation method and application thereof
-
, (2021/06/12)
The invention discloses an azo dye represented by formula I shown in the specification, and a preparation method and application thereof. The azo dye provided by the invention has remarkably high dichroism, the solubility of the azo dye in a liquid crystal medium can reach 2 wt% or above, and when the azo dye is applied to a guest-host liquid crystal composition, a liquid crystal display device containing the guest-host liquid crystal composition can have higher contrast.
Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines
Kelley,Linn,Selway
, p. 1757 - 1763 (2007/10/02)
A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.
