24190-77-0

Basic information

• Product Name: 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester
• Synonyms: 4-acetylaMino-5-chloro-2-hydroxybenzoate;Methyl 5-chloro-4-acetaMido-2-hydroxybenzoate;Methyl 4-acetylaMino-5-chloro-2-hdroxybenzoate;4-acetylamino-5-chloro-2-methoxybenzoate;4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester;4-Acetamido-5-chloro-2-hydroxybenzoic acid methyl ester;METHYL 4-ACETYLAMINO-5-CHLORO-2-HYDROXYBENZOATE;Benzoicacid, 4-(acetylamino)-5-chloro-2-hydroxy-, methyl ester
• CAS NO: 24190-77-0
• Molecular Formula: C₁₀H₁₀ClNO₄
• Molecular Weight: 243.6437
• EINECS: 246-857-6
• Mol File: 24190-77-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 145-146℃
• Boiling Point: 428.2 °C at 760 mmHg
• Flash Point: 212.7 °C
• Appearance: /
• Density: 1.426
• Vapor Pressure: 6.21E-08mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.87±0.23(Predicted)
• CAS DataBase Reference: 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester(24190-77-0)
• EPA Substance Registry System: 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester(24190-77-0)

Safety Data

• Hazardous Substances Data: 24190-77-0(Hazardous Substances Data)

Usage

General Description

4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester is a chemical compound with the molecular formula C10H9NO4Cl. It is a methyl ester derivative of 5-chlorosalicylic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester has been studied for its potential anti-inflammatory and analgesic properties, as well as its ability to inhibit the growth of certain cancer cells. It is also used as a reagent in organic synthesis and as a building block for the preparation of various bioactive compounds. Due to its versatile properties, 4-Acetylamino-5-Chloro-2-Hydroxybenzoic Acid Methyl Ester has applications in both the pharmaceutical and chemical industries.

InChI:InChI=1/C10H10ClNO4/c1-5(13)12-8-4-9(14)6(3-7(8)11)10(15)16-2/h3-4,14H,1-2H3,(H,12,13)

Upstream product

• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 89481-87-8 methyl 4-(acetylamino)-5-chloro-2-(2-propynyloxy)benzoate 
• 186581-53-3 diazomethane 
• 21386-96-9 4-acetylamino-5-chlorosalicylic acid 
• 4136-97-4 methyl 4-aminosalicylate 
• 65-49-6 4-Aminosalicylic acid 

Downstream Products

• 483303-87-3 4-acetylamino-2-butoxy-5-chloro-benzoic acid methyl ester 
• 483303-86-2 4-acetylamino-2-benzyloxy-5-chloro-benzoic acid methyl ester 
• 111049-87-7 methyl 4-acetylamino-2-allyloxy-5-chlorobenzoate 
• 89481-87-8 methyl 4-(acetylamino)-5-chloro-2-(2-propynyloxy)benzoate 
• 232941-14-9 4-acetamido-3-bromo-5-chloro-2-hydroxybenzoic acid methyl ester 
• 143878-29-9 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid methyl ester 
• 123654-26-2 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid 
• 935696-96-1 4-amino-5-chlorobenzofuran-7-carboxylic acid 
• 1613730-56-5 methyl 4-acetamido-5-chloro-2-(((trifluoromethyl)sulfonyl)oxy)benzoate 
• 1613730-59-8 methyl 4-amino-5-chloro-2-methyl-3-((trimethylsilyl)ethynyl)benzoate 
• 1613730-58-7 methyl 4-amino-5-chloro-3-iodo-2-methylbenzoate 
• 1427361-27-0 methyl 4-amino-5-chloro-2-methylbenzoate 
• 1613730-57-6 methyl 4-acetamido-5-chloro-2-methylbenzoate 
• 179872-38-9 4-acetylamino-5-chloro-3-iodo-2-methoxybenzoic acid 

Relevant articles and documents

Preparation method of key intermediate 4-amino-5-halobenzofuran-7-carboxylic acid of 5-HT4 receptor stimulant

The invention discloses a preparation method of a key intermediate 4-amino-5-halobenzofuran-7-carboxylic acid of a 1,5-HT4 receptor stimulant, belonging to the field of organic synthesis. According tothe preparation method, para-protected amino-o-hydroxybenzoic acid/hydroxybenzoate, a halogenating reagent and triethyl acetenyl silicon are used as main raw materials, and a three-step reaction is performed to obtain the 4-amino-5-halobenzofuran-7-carboxylic acid. The method has the advantages of simple process operation, short reaction steps, easy separation of the intermediate, total yield ofmore than 51%, usage cheap and easily available raw materials and greatly reduced production cost; and thus, the method has obvious competitive advantages.

AMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

The present invention relates to compounds of formula (I), including their stereoisomers and pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-hydroxytryptamine 4 (5-HT4) receptor.

HETEROARYL COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS

The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HT4 receptors.