24201-13-6

Basic information

• Product Name: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid
• Synonyms: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid;4-ACETAMIDO-5-CHLORO-O-ANISIC ACID;4-ACETAMIDO-5-CHLORO-2-METHOXYBENZOIC ACID,95% MIN(HPLC);4-Acetamido-5-chloro-2-methoxybenzoic acid;4-Acetamino-5-chloro-2-methoxybenzoic acid
• CAS NO: 24201-13-6
• Molecular Formula: C₁₀H₁₀ClNO₄
• Molecular Weight: 243.6437
• Mol File: 24201-13-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 188 ºC
• Boiling Point: 454.615 °C at 760 mmHg
• Flash Point: 228.743 °C
• Appearance: /
• Density: 1.424
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.607
• PKA: 3.79±0.10(Predicted)
• CAS DataBase Reference: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid(24201-13-6)
• EPA Substance Registry System: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid(24201-13-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 24201-13-6(Hazardous Substances Data)

Usage

General Description

4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid is a chemical compound with the molecular formula C10H10ClNO4. It is a derivative of salicylic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid has potential medical applications, particularly as an anti-inflammatory and analgesic agent. Its structure includes an acetamino group, a chlorine atom, and a methoxy group attached to a benzoic acid backbone, making it a versatile and important building block in organic chemistry. Additionally, its unique molecular structure and properties also make it a valuable tool for drug discovery and development.

InChI:InChI=1/C10H10ClNO4/c1-5(13)12-8-4-9(16-2)6(10(14)15)3-7(8)11/h3-4H,1-2H3,(H,12,13)(H,14,15)

Upstream product

• 4093-31-6 methyl 2-methoxy 4-acetamido 5-chloro benzoate 

Downstream Products

• 55-21-0 benzamide 
• 70181-03-2 4-Amino-5-chloro-2-methoxy-N-(1.2-diethyl-4-pyrazolidinyl)benzamide 
• 67092-46-0 4-acetylamino-5-chloro-2-methoxy-N-(2-quinolizidinyl)-benzamide 
• 439145-96-7 4-acetylamino-N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-methoxybenzamide 
• 56594-06-0 N-ethyl-7-(2-methoxy-4-amino-5-chloro benzamido methyl)-8-azabicyclo (4,3,0)nonane 
• 50734-06-0 4-Amino-5-chloro-2-methoxy-N-(1-methyl-3-pyrrolidinyl)benzamide 
• 56594-05-9 N-ethyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo(3,3,0) octane 
• 78991-40-9 4-amino-5-chloro-2-methoxy-N-[4-(3-thenyl)-1-piperazinyl]-benzamide 
• 65504-30-5 4-acetylamino-5-chloro-2-methoxy-N-[4-ethyl-1-piperazinyl]benzamide 
• 65504-21-4 4-amino-5-chloro-N-(4-ethyl-piperazin-1-yl)-2-methoxy-benzamide 
• 72135-09-2 N-(1-cyclohexyl-2-pyrrolidinyl-methyl)-2-methoxy-4-amino-5-chlorobenzamide 
• 171804-67-4 4-(Acetylamino)-5-chloro-N-(hexahydro-2,6-methano-1H-pyrrolizin-8-ylmethyl)-2-methoxybenzamide, hydrochloride 
• 7206-70-4 4-amino-5-chloro-2-methoxybenzoic acid 
• 4516-32-9 4-acetylamino-5-chloro-2-methoxy-benzoyl chloride 

Relevant articles and documents

Synthesis

The present invention provides an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride, compositions thereof, and intermediates thereto.

NF-KB ACTIVATION INHIBITORS

A medicament having inhibitory activity against NF-κB activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1○ a fused polycyclic heteroaryl group wherein the ring which binds directly to ―CONH― group in the formula (I) is a benzene ring, 2○ unsubstituted thiazol-2-yl group, or 3○ unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ― CONH―E wherein E has the same meaning as that defined above.

REMEDIES FOR NEURODEGENERATIVE DISEASES

A medicament for preventive and/or therapeutic treatment of neurodegenerative diseases such as Alzheimer's disease or the like which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1○ a fused polycyclic heteroaryl group wherein the ring which binds directly to -CONH- group in the formula (I) is a benzene ring, 2○ unsubstituted thiazol-2-yl group, or 3○ unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above.