24209-38-9 Usage
Description
7-TMCA, also known as 7-Amino-3-(1-methyl-5-tetrazolylthio)methyl-3-cephem-4-carboxylic Acid, is a cephalosporin derivative with potent antibacterial properties. It is characterized by its off-white solid appearance and plays a crucial role as an intermediate in the preparation of various semi-synthetic antibiotics, including Cefmetazole (C242850).
Uses
Used in Pharmaceutical Industry:
7-TMCA is used as an intermediate for the synthesis of semi-synthetic antibiotics, such as Cefmetazole (C242850), due to its potent antibacterial activity. This application is significant in the development of new and effective treatments for bacterial infections.
Used in Antibacterial Applications:
7-TMCA is utilized as an active pharmaceutical ingredient in the formulation of antibiotics, specifically cephalosporin-based drugs. Its role in these medications is to combat bacterial infections by disrupting the bacterial cell wall synthesis, ultimately leading to the eradication of the infection.
Used in Research and Development:
In the field of pharmaceutical research and development, 7-TMCA serves as a valuable compound for studying the structure-activity relationships of cephalosporin derivatives. This knowledge aids in the design and development of novel antibiotics with improved properties, such as enhanced potency, selectivity, and reduced side effects.
Used in Quality Control and Standardization:
7-TMCA is employed as a reference compound in the quality control and standardization of cephalosporin-based antibiotics. Its use ensures that the final products meet the required specifications and maintain a consistent level of efficacy and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 24209-38-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,2,0 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 24209-38:
(7*2)+(6*4)+(5*2)+(4*0)+(3*9)+(2*3)+(1*8)=89
89 % 10 = 9
So 24209-38-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N6O3S2/c1-15-10(12-13-14-15)21-3-4-2-20-8-5(11)7(17)16(8)6(4)9(18)19/h5,8H,2-3,11H2,1H3,(H,18,19)/t5-,8-/m0/s1
24209-38-9Relevant articles and documents
New adaptation diseases of cefoperazone medicinal preparation for treating endometritis and other gynecological genital tract infections
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Paragraph 0108; 0109; 0115-0126; 0141-0142, (2020/08/22)
The invention discloses new adaptation diseases of cefoperazone medicinal preparation for treating gynecological genital tract infections of gynecology department. The cefoperazone sodium provided bya specific raw material production process is extremely low in impurity content and remarkable in medicine effect, so that the quality of a preparation product is improved, the safety and effectiveness of the preparation product are guaranteed, and the invention provides the application of preparing the medicine for treating endometritis and other gynecological genital tract infections.
1/5 water cefamandole sodium compound
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Paragraph 0029; 0030, (2017/07/20)
The invention discloses a 1/5 water cefamandole sodium compound and a preparation method thereof. Each mol of cefamandole sodium compound contains 1/5 mol of water. The cefamandole sodium compound prepared by the method disclosed by the invention has low impurity content and good stability and has a wider application prospect.
A novel synthetic route to 7-MAC from 7-ACA
Xiong, Fei,Li, Gen,Song, Bo,Chen, Fen-Er,Zeng, Zhao-Sen
, p. 1019 - 1025 (2016/05/02)
An efficient and practical seven-step procedure is described for the synthesis of (6R,7S)-benzhydryl-7-amino-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo [4.2.0]oct-2-ene-2-carboxylate (7-MAC, 3) with overall yield of 49?%. This synthesis features a convenient and highly selective method for the introduction of 7α-methoxy group to cephalosporin nucleus in 10 using MeOLi/t-BuOCl in THF.
