24284-84-2

Basic information

• Product Name: Sts 64
• Synonyms: Sts 64;17 alpha-cyanomethylestradiol 3-methyl ether;2-[(8R,9S,13S,14S,17R)-17-hydroxy-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]acetonitrile
• CAS NO: 24284-84-2
• Molecular Formula: C21H27 N O2
• Molecular Weight: 325.44
• Mol File: 24284-84-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 508.8°Cat760mmHg
• Flash Point: 261.5°C
• Appearance: /
• Density: 1.131g/cm³
• Vapor Pressure: 3.55E-11mmHg at 25°C
• Refractive Index: 1.563
• PKA: 13.71±0.40(Predicted)
• CAS DataBase Reference: Sts 64(CAS DataBase Reference)
• NIST Chemistry Reference: Sts 64(24284-84-2)
• EPA Substance Registry System: Sts 64(24284-84-2)

Safety Data

• Hazardous Substances Data: 24284-84-2(Hazardous Substances Data)

Usage

Description

Sts 64 is a compound with various applications across different industries, including pharmaceuticals and contraceptives. It is known for its ability to decrease blood cholesterol levels in women with hypercholesterolemia and is also an impurity in Dienogest, a useful contraceptive agent.

Uses

Used in Pharmaceutical Industry:
Sts 64 is used as an impurity in Dienogest (D441870), a contraceptive agent, for its role in family planning and reproductive health.
Used in Healthcare Industry:
Sts 64 is used to decrease blood cholesterol levels in women with hypercholesterolemia, contributing to the management and treatment of cardiovascular diseases.

InChI:InChI=1/C21H27NO2/c1-20-9-7-17-16-6-4-15(24-2)13-14(16)3-5-18(17)19(20)8-10-21(20,23)11-12-22/h4,6,13,17-19,23H,3,5,7-11H2,1-2H3/t17-,18-,19+,20+,21-/m1/s1

Upstream product

• 1624-62-0 estrone 3-methyl ether 
• 75-05-8 acetonitrile 
• 65928-58-7 Dienogest 
• 67473-36-3 17α-Cyanomethyl-17β-hydroxyestr-4-en-3-one 

Relevant articles and documents

METHOD FOR SYNTHESIS OF DIENOGEST FROM ESTRONE-3-METHYLETHER

A method for the synthesis of dienogest from 3-methoxy-estra-1,3,5-trien-17-one includes the steps of a) reacting 3-methoxy-estra-1,3,5-trien-17-one with alcohol in the presence of an acid in an organic solvent to form 3-methoxy-17,17-dialkoxy-estra-1,3,5

MICROBIAL TRANSFORMATION OF 17α-CYANOMETHYL-17-HYDROXY-4,9-ESTRADIEN-3-ONE (STS 557) AND 17α-CYANOMETHYL-19-NORTESTOSTERONE BY MYCOBACTERIUM SMEGMATIS

Microbial transformation of the new progestagen STS 557 (17α-cyanomethyl-17-hydroxy-4,9-estradien-3-one) by Mycobacterium smegmatis yielded predominantly ring A-aromatized compounds. 17α-cyanomethyl-1,3,5(10),9(11)-estratetraene-3,17-diol, 17α-cyanomethyl-1,3,5(10)-estratriene-3,17-diol and the corresponding 3-methyl ethers.The analogous compound without the 9(10) double bound, 17α-cyanomethyl-19-nortestosterone, was transformed mainly to 5α-hydrogenated metabolites: 17α-cyanomethyl-17-hydroxy-5α-estran-3-one, 17α-cyanomethyl-17-hydroxy-5α-1-estren-3-one, 17α-cyanomethyl-5α-estrane-3α,17-diol, and 17α-cyanomethyl-5α-estrane- 3β,17-diol.From these results, it is concluded that 4,9-dien-3-oxo compounds are not substrates for enzymatic 5α-hydrogenation.