24347-63-5Relevant articles and documents
Lyngbyabellins K-N from two Palmyra atoll collections of the marine cyanobacterium Moorea bouillonii
Choi, Hyukjae,Mevers, Emily,Byrum, Tara,Valeriote, Frederick A.,Gerwick, William H.
, p. 5141 - 5150 (2012)
Five lipopeptides of the lyngbyabellin structure class, four cyclic (1-3 and 5) and one linear (4), were isolated from the extracts of two collections of filamentous marine cyanobacteria obtained from the Palmyra Atoll in the Central Pacific Ocean. Their
Kinetic Resolution of Chiral α-Hydroperoxy Esters by Horseradish Peroxidase-Catalyzed Enantioselective Reduction to α-Hydroxy Esters
Adam, Waldemar,Fell, Rainer T.,Hoch, Ute,Saha-Mueller, Chantu R.,Schreier, Peter
, p. 1047 - 1050 (1995)
The kinetic resolution of the methyl α-hydroperoxy esters 4 has been investigated by horseradish peroxidase (HRP)-catalyzed reduction to the corresponding optically active α-hydroxy esters 5 in the presence of guaiacol.The method allows for the first time the preparation of enantiomerically pure (ee>97percent) methyl (R)-2-hydroperoxybutyrate (4a).The HRP enzyme is sensitive to the steric demand of the ester alkyl side chain, as manifested by ethyl (ee>97percent) and isopropyl (ee 79percent), while the tert-butyl derivative is not accepted by the enzyme (no reduction).
Isolation and Total Synthesis of Kinenzoline, an Antitrypanosomal Linear Depsipeptide Isolated from a Marine Salileptolyngbya sp. Cyanobacterium
Kurisawa, Naoaki,Otomo, Keisuke,Iwasaki, Arihiro,Jeelani, Ghulam,Nozaki, Tomoyoshi,Suenaga, Kiyotake
, p. 12528 - 12536 (2021/09/20)
Kinenzoline (1), a new linear depsipeptide, was isolated from a marine Salileptolyngbya sp. cyanobacterium. Its structure was elucidated by spectroscopic analyses and degradation reactions. In addition, we achieved a total synthesis of 1 and confirmed its structure. Kinenzoline (1) showed highly selective antiproliferative activity against the causative organism of sleeping sickness, Trypanosoma brucei rhodesiense (IC50 4.5 μM), compared to normal human cells (WI-38, IC50 > 100 μM). Kinenzoline (1) is a promising lead compound for the development of new antitrypanosomal drugs.
INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN
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Page/Page column 101, (2020/03/23)
Disclosed are small molecule inhibitors of ανβ6 integrin, and methods of using them to treat a number of diseases and conditions. Applicants have discovered novel ανβ6 integrin inhibitor compounds and evaluated the possession, performance and utility of r