2439-37-4Relevant articles and documents
Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia
Bitchi, Michel Boni,Magid, Abdulmagid Alabdul,Kabran, Faustin Aka,Yao-Kouassi, Philomène Akoua,Harakat, Dominique,Morjani, Hamid,Tonzibo, Félix Zanahi,Voutquenne-Nazabadioko, Laurence
, (2019/08/12)
Heisteria parvifolia Sm. is prescribed in traditional medecine against numerous diseases in C?te d'Ivoire. Due to the shortcoming in scientifical knowledge of use of this species, our investigations revealed five undescribed cyclopeptide alkaloids added to one known derivative namely anorldianine. These compounds were elucidated by 1D and 2D-NMR experiments and comparison with literature data, and confirmed by HR-ESI-MS. Cytotoxic activity evaluation of these compounds against the chronic myeloid leukemia (K565) cell line exhibited an antiproliferative activity with cell growth inhibition from 13% to 46%.
Reduced dipeptide analogues as calcium channel antagonists
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, (2008/06/13)
The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke, cerebral ischemia, pain, epilepsy, and head trauma. The nov