243973-20-8Relevant articles and documents
Method for preparing 2-arylmalonic acid derivative, intermediate and application thereof
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Paragraph 0054-0055, (2020/07/15)
The invention provides a method for preparing a 2-arylmalonic acid derivative, an intermediate and application thereof. According to the method, a cyclohexadiene compound is used as a raw material, and the 2-arylmalonic acid derivative 3 is obtained through an isomerization reaction, a halogenation reaction in the presence of a halogenation reagent and a dehydrohalogenation aromatization reactionat a certain temperature in sequence. Compared with the prior art, the method has the following remarkable characteristics and advantages: (1) expensive metal catalysts are not needed in the reaction;(2) strong base with potential safety hazards is not needed in the reaction; and (3) the reaction is safe, the conditions are mild, the yield is high, the cost is low, and industrial production is facilitated.
METHOD FOR PREPARING 2-ARYL MALONAMIDE AND APPLICATIONS THEREOF
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Paragraph 0025-0026, (2020/02/13)
Disclosed are a method for preparing 2-aryl malonamide and an application thereof. This method uses 2-(cyclohexenylidene) malononitrile as a raw material, which undergoes an aromatization-hydrolyzation reaction in the presence of an oxidant and water to produce 2-aryl malonamide by one step. Compared to the prior art, the method for preparing 2-aryl malonamide of this application has the following features and advantages: (1) this method employs a completely different synthetic strategy; (2) raw materials used in this method are easily obtained; (3) this method not only has high yield, but also does not require expensive metal catalysts. This method is lower-cost, suitable for the industrial production.
Preparation method of pinoxaden
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, (2019/12/25)
The invention relates to the field of organic synthesis, in particular to a synthesis method of pinoxaden. The synthesis method comprises the following steps that under catalysis of copper chloride orcuprous chloride, 4-methyl-2,6-diethyl aniline reacts with 1,1-dichloroethylene and nitrous acid ester to generate a compound 1; the compound 1 reacts with sodium alcoholate, and a reaction product is subjected to acidic hydrolysis to obtain a compound 2; the compound 2 reacts with diester carbonate and strong base to obtain an intermediate 3; after diethylene glycol dimethanesulfonate reacts with hydrazine hydrate, salifying with hydrochloric acid is conducted to obtain an intermediate 4; the intermediate 3 and the intermediate 4 are subjected to ring forming under the effect of base to obtain a compound 5; and the compound 5 and pivaloyl chloride react under the effect of the base or base/DMAP to obtain the pinoxaden. The synthesis method of the pinoxaden does not use expensive or toxiccatalysts, does not need to adopt a protection/deprotection strategy, and has the characteristics of low cost and high atomic economy.