244263-45-4

Basic information

• Product Name: 1-(6-CHLOROPYRIDIN-3-YL)-2-METHYLPROPAN-1-ONE
• Synonyms: 1-(6-CHLOROPYRIDIN-3-YL)-2-METHYLPROPAN-1-ONE;1-PROPANONE, 1-(6-CHLORO-3-PYRIDINYL)-2-METHYL
• CAS NO: 244263-45-4
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.63
• Product Categories: pharmacetical
• Mol File: 244263-45-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 297.8 °C at 760 mmHg
• Flash Point: 133.9 °C
• Appearance: /
• Density: 1.151 g/cm³
• Vapor Pressure: 0.00132mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 1-(6-CHLOROPYRIDIN-3-YL)-2-METHYLPROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-CHLOROPYRIDIN-3-YL)-2-METHYLPROPAN-1-ONE(244263-45-4)
• EPA Substance Registry System: 1-(6-CHLOROPYRIDIN-3-YL)-2-METHYLPROPAN-1-ONE(244263-45-4)

Safety Data

• Hazardous Substances Data: 244263-45-4(Hazardous Substances Data)

Usage

General Description

1-(6-Chloropyridin-3-yl)-2-methylpropan-1-one is a chemical compound with the molecular formula C10H10ClNO. It is a ketone derivative with a pyridine ring and a chlorine atom attached to it. The compound also contains a methyl group and a 2-methylpropan-1-one group. This chemical is used in pharmaceutical and research applications, as well as in the production of various organic compounds. It may also have potential uses in medicinal chemistry and drug development due to its unique structure and properties.

InChI:InChI=1/C9H10ClNO/c1-6(2)9(12)7-3-4-8(10)11-5-7/h3-6H,1-2H3

Upstream product

• 920-39-8 isopropylmagnesium bromide 
• 149281-42-5 6-chloro-N-methoxy-N-methylpyridine-3-carboxamide 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 1068-55-9 isopropylmagnesium chloride 

Relevant articles and documents

A concise route to novel 1-aryl and 1-pyridyl-2-azabicyclo[2.1.1]hexanes

A number of novel 1-aryl and 1-pyridyl-2-azabicyclo[2.1.1]hexane derivatives were prepared by an intramolecular [2+2] photocycloaddition in the presence of acetophenone as the sensitizer. Substitution of the azabicyclo[2.1.1]hexane ring was accomplished by appropriate choice of the heteroaryl ketone and allylamine starting materials. Several aryl 9a-e, g and pyridyl analogs 9h-l were prepared by this method. The structures of 9a and 9i were verified by X-ray crystallography. Several of the photoproducts 9 were converted into the corresponding N-Me and N-H 2,4-methanonicotine analogs 4 by reduction or hydrolysis of the N-carboethoxy group.

Addition of Grignard reagents to aryl acid chlorides: An efficient synthesis of aryl ketones

(Chemical Equation Presented) Direct addition of Grignard reagents to acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether proceeds selectively to provide aryl ketones in high yields. A possible tridentate interaction between Grignard reagents and bis[2-(N,N-dimethylamino)ethyl] ether moderates the reactivity of Grignard reagents, preventing the newly formed ketones from nucleophilic addition by Grignard reagents.