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24463-19-2 Usage

Chemical Properties

YELLOW POWDER

Uses

9-(Chloromethyl)anthracene is used as a blocking group reagent used for carboxylic acids, phenols, mercaptans and thiophenols. It is a derivatizing agent for carboxylic acids giving esters with enhanced UV and fluorescence detection in HPLC.

Application

9-Anthracenylmethyl Chloride is a derivative of Anthracene which is an important source of dyestuffs. It is a reagent for the protection of carboxylic acids, alcohols, phenols and thiols as their 9-anthrylmethyl derivatives, which are stable to mild acid or base, but specifically cleaved by NaSMe.

Reactions

Lepidopterene, a tetrabenzotetracyclotetradecatetraene, was first synthesized by reaction of 9-(chloromethyl)anthracene with methylmagnesium iodide. Through this methodology, lepidopterene and 1,2-bis(9-anthracenyl)ethane were obtained in 35% and 30% yield, respectively.An easy synthesis of lepidopterene from 9-chloromethylanthracene

Purification Methods

If it is free from OH in the IR then recrystallisation from hexane/*C6H6 or *C6H6 (as needles). If OH is present, then some solvolysis has occurred. In this case treat 8.5g of it with SOCl2 (4.8g) in dioxane (60mL) and reflux for 5hours, then evaporate to dryness and wash the residue with cold *C6H6 and recrystallise it. With KI/Me2CO it forms the iodomethyl derivative. [Fierens et al. Helv Chim Acta 38 2009 1955, Hunter et al. J Org Chem 21 1512 1956, Beilstein 5 III 3152, 5 IV 2313.]

Check Digit Verification of cas no

The CAS Registry Mumber 24463-19-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,4,6 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 24463-19:
(7*2)+(6*4)+(5*4)+(4*6)+(3*3)+(2*1)+(1*9)=102
102 % 10 = 2
So 24463-19-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H11Cl/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)15/h1-9H,10H2

24463-19-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A13579)  9-(Chloromethyl)anthracene, 98+%   

  • 24463-19-2

  • 1g

  • 315.0CNY

  • Detail
  • Alfa Aesar

  • (A13579)  9-(Chloromethyl)anthracene, 98+%   

  • 24463-19-2

  • 5g

  • 1183.0CNY

  • Detail
  • Alfa Aesar

  • (A13579)  9-(Chloromethyl)anthracene, 98+%   

  • 24463-19-2

  • 25g

  • 3158.0CNY

  • Detail
  • Sigma

  • (25102)  9-(Chloromethyl)anthracene  BioReagent, suitable for fluorescence, ≥97.0% (AT)

  • 24463-19-2

  • 25102-5G-F

  • 2,109.51CNY

  • Detail
  • Aldrich

  • (196517)  9-(Chloromethyl)anthracene  ≥98%

  • 24463-19-2

  • 196517-2.5G

  • 1,205.10CNY

  • Detail
  • Aldrich

  • (196517)  9-(Chloromethyl)anthracene  ≥98%

  • 24463-19-2

  • 196517-10G

  • 3,758.04CNY

  • Detail

24463-19-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-(Chloromethyl)anthracene

1.2 Other means of identification

Product number -
Other names 9-anthracenylmethyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24463-19-2 SDS

24463-19-2Synthetic route

anthracen-9-ylmethylene-hydrazine
7512-18-7

anthracen-9-ylmethylene-hydrazine

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

Conditions
ConditionsYield
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -78 - 20℃;98%
9-hydroxymethylanthracene
1468-95-7

9-hydroxymethylanthracene

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

Conditions
ConditionsYield
With thionyl chloride In 1,4-dioxane for 5h; Heating;95%
With thionyl chloride In dichloromethane for 2h; Substitution; Heating;87.9%
With thionyl chloride In tetrahydrofuran for 5h; Reflux; Inert atmosphere;85%
9-methylanthracene
779-02-2

9-methylanthracene

A

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

B

9-chloro-10-methylanthracene
19096-07-2

9-chloro-10-methylanthracene

Conditions
ConditionsYield
With hydrogenchloride In tetrachloromethane for 1h; Chlorination; Heating;A 9%
B 32%
9-(phenoxymethyl)anthracene
16430-34-5

9-(phenoxymethyl)anthracene

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

Conditions
ConditionsYield
With dichloromethane Substitution; laser-jet photolysis;100 % Spectr.
9-anthracene aldehyde
642-31-9

9-anthracene aldehyde

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Magnesium / 1.) Ether, 2.) THF, 40 deg C, 30 min
2: Thionyl chloride / benzene / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: Sodium borohydride / methanol; H2O / 1.) 50 deg C, 2.) RT, 1.5 h
2: Thionyl chloride / benzene / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: LiAlH4; diethyl ether
2: benzene; PCl5
View Scheme
Stage #1: 9-anthracene aldehyde With methanol; sodium tetrahydroborate at 0℃;
Stage #2: With thionyl chloride In dichloromethane at 0℃;
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; ethanol / 2 h / 40 °C
2: thionyl chloride / tetrahydrofuran / 5 h / Reflux; Inert atmosphere
View Scheme
9-anthracene aldehyde
642-31-9

9-anthracene aldehyde

A

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

B

H2O-dioxane mixtures

H2O-dioxane mixtures

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBH4
2: HCl
View Scheme
Multi-step reaction with 2 steps
1: aq. NaBH4
2: SOCl2
View Scheme
anthracene
120-12-7

anthracene

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trichlorophosphate / 80 °C
2.1: sodium tetrahydroborate; methanol / 0 °C
2.2: 0 °C
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate / chlorobenzene / 2 h / Schlenk technique; Inert atmosphere; Reflux
2: sodium tetrahydroborate; ethanol / 2 h / 40 °C
3: thionyl chloride / tetrahydrofuran / 5 h / Reflux; Inert atmosphere
View Scheme
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

1-[(9-anthracenyl)methyl]-3-methylimidazolium chloride
61865-02-9

1-[(9-anthracenyl)methyl]-3-methylimidazolium chloride

Conditions
ConditionsYield
In tetrahydrofuran at 60℃; for 24h; Inert atmosphere;100%
In acetonitrile for 48h; Inert atmosphere; Darkness; Reflux;92%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

potassium cyanide
151-50-8

potassium cyanide

anthracen-9-yl-acetonitrile
2961-76-4

anthracen-9-yl-acetonitrile

Conditions
ConditionsYield
In acetonitrile for 2h; Heating;99%
In acetonitrile for 2h; Heating / reflux;98%
In dimethyl sulfoxide
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

2,8-dithia-5-aza-2,6-pyridinophane
771500-52-8

2,8-dithia-5-aza-2,6-pyridinophane

5-(9-anthracenylmethyl)-2,8-dithia-5-aza-2,6-pyridinophane

5-(9-anthracenylmethyl)-2,8-dithia-5-aza-2,6-pyridinophane

Conditions
ConditionsYield
With potassium carbonate In dichloromethane for 24h; Heating;99%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

9-(azidomethyl)anthracene
195133-98-3

9-(azidomethyl)anthracene

Conditions
ConditionsYield
With sodium azide; tetrabutylammomium bromide In N,N-dimethyl-formamide at 79.84℃; for 1h;99%
With sodium azide; 18-crown-6 ether; tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 20℃; Inert atmosphere;95%
With sodium azide In N,N-dimethyl-formamide at 20℃;95%
sodium cyanide
773837-37-9

sodium cyanide

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

anthracen-9-yl-acetonitrile
2961-76-4

anthracen-9-yl-acetonitrile

Conditions
ConditionsYield
In dimethylsulfoxide-d6 at 55℃; for 4h; Inert atmosphere;99%
In N,N-dimethyl-formamide for 12h;93%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

4-anthracen-9-ylmethylpiperazine-1-carboxylic acid tert-butyl ester
1419212-75-1

4-anthracen-9-ylmethylpiperazine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 18h; Reflux; Inert atmosphere;99%
With potassium carbonate In acetonitrile at 60℃;89%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

C20H26N2S2
109467-83-6

C20H26N2S2

C50H46N2S2

C50H46N2S2

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 47.5h; Inert atmosphere; Reflux;98.8%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

Cinchonin
118-10-5

Cinchonin

(2R,5R,1'S)-1-(9-anthracenyl)methyl-5-ethylene-2-[1-hydroxy-1-(quinol-4-yl)]methyl-1-azoniabicyclo[2.2.2]octane chloride

(2R,5R,1'S)-1-(9-anthracenyl)methyl-5-ethylene-2-[1-hydroxy-1-(quinol-4-yl)]methyl-1-azoniabicyclo[2.2.2]octane chloride

Conditions
ConditionsYield
In toluene at 110℃; for 2h;98%
In toluene Reflux;94%
In toluene for 24h; Heating;80%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

potassium phtalimide
1074-82-4

potassium phtalimide

N-(9-anthranylmethyl)phthalimide
94617-21-7

N-(9-anthranylmethyl)phthalimide

Conditions
ConditionsYield
With 18-crown-6 ether In toluene for 6h; Heating;98%
In N,N-dimethyl-formamide at 60℃; for 3h;
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

[3,5-bis[[3,5-bis[[3,5-bis(phenylmethoxy)phenyl]methoxy]phenyl]methoxy]phenyl]methyl alcohol
137472-16-3

[3,5-bis[[3,5-bis[[3,5-bis(phenylmethoxy)phenyl]methoxy]phenyl]methoxy]phenyl]methyl alcohol

9-[(3,5-bis{3,5-bis[3,5-bis(benzyloxy)benzyloxy]benzyloxy}benzyloxy)methyl]anthracene

9-[(3,5-bis{3,5-bis[3,5-bis(benzyloxy)benzyloxy]benzyloxy}benzyloxy)methyl]anthracene

Conditions
ConditionsYield
With potassium hydroxide; tetrabutylammomium bromide In water; chlorobenzene at 60℃; for 72h;98%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

1,4,7-trithia-10-azacyclododecane
122011-96-5

1,4,7-trithia-10-azacyclododecane

1-(9-anthracenylmethyl)-1-aza-4,7,10-trithiacyclododecane
1219634-78-2

1-(9-anthracenylmethyl)-1-aza-4,7,10-trithiacyclododecane

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 168h; Inert atmosphere;98%
With triethylamine In tetrahydrofuran Inert atmosphere; Reflux;11.8%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

quinolin-4-yl((1S,2S,4S,5R)-5-vinyl-quinuclidin-2-yl)methanol
118-10-5, 485-70-1, 485-71-2, 550-54-9, 40134-63-2, 72402-55-2, 72402-56-3

quinolin-4-yl((1S,2S,4S,5R)-5-vinyl-quinuclidin-2-yl)methanol

(1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-(hydroxy(quinolin-4-yl)methyl)-5-vinyl-quinuclidin-1-ium chloride

(1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-(hydroxy(quinolin-4-yl)methyl)-5-vinyl-quinuclidin-1-ium chloride

Conditions
ConditionsYield
In toluene at 110℃; for 2h;98%
In toluene for 6h; Reflux; Inert atmosphere;970 mg
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

N-(anthracen-9-yl-methyl)bis(2-hydroxyethyl)amine
109297-66-7

N-(anthracen-9-yl-methyl)bis(2-hydroxyethyl)amine

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In chloroform; acetonitrile for 2.5h; Alkylation; Heating;97%
With potassium carbonate In toluene for 24h; Heating;62%
pentaethylene glycol
2615-15-8

pentaethylene glycol

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

(9-anthracenylmethyl)hexaethylene glycol
327602-40-4

(9-anthracenylmethyl)hexaethylene glycol

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide for 24h;97%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

C13H18N2

C13H18N2

1-(isobutyl)-3-(anthracen-9-ylmethyl)-5,6-dimethylbenzimidazolium chloride

1-(isobutyl)-3-(anthracen-9-ylmethyl)-5,6-dimethylbenzimidazolium chloride

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere; Schlenk technique;97%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

N-(diphenylmethylene)glycine tert-butyl ester
81477-94-3

N-(diphenylmethylene)glycine tert-butyl ester

(S)-tert-butyl 3-(9-methylanthracenyl)-2-diphenylmethyleneaminopropanoate

(S)-tert-butyl 3-(9-methylanthracenyl)-2-diphenylmethyleneaminopropanoate

Conditions
ConditionsYield
With potassium hydroxide In chloroform; water; toluene at 0℃; for 0.5h;96%
With potassium hydroxide; 2,7-[bis((-)-hydrocinchonidine)methyl]naphthalene In chloroform; water; toluene at 0℃; for 2h;95%
With potassium hydroxide; O(9)-All-N-(2',3',4'-trifluorobenzyl)hydrocinchonidinium bromide In chloroform; water; toluene at -20℃; for 10h;95%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

allenyltributylstannane
53915-69-8

allenyltributylstannane

10-methylene-9-(propa-1,2-dienyl)-9,10-dihydroanthracene
1221432-97-8

10-methylene-9-(propa-1,2-dienyl)-9,10-dihydroanthracene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In dichloromethane at 20℃; for 12h; Inert atmosphere;96%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

1,3-Phenylenebis(methylene)selenocyanate
59395-13-0

1,3-Phenylenebis(methylene)selenocyanate

1,3-bis[(selenomethylanthryl)methyl]benzene

1,3-bis[(selenomethylanthryl)methyl]benzene

Conditions
ConditionsYield
Stage #1: 1,3-Phenylenebis(methylene)selenocyanate With sodium tetrahydroborate In tetrahydrofuran; ethanol for 1h; Reduction;
Stage #2: anthracenylmethyl chloride In tetrahydrofuran; ethanol for 24h; Alkylation;
95%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-phenyl]-methanol
129536-40-9

[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-phenyl]-methanol

9-({3,5-bis[3,5-bis(benzyloxy)benzyloxy]benzyloxy}methyl)anthracene
496839-77-1

9-({3,5-bis[3,5-bis(benzyloxy)benzyloxy]benzyloxy}methyl)anthracene

Conditions
ConditionsYield
With potassium hydroxide; tetrabutylammomium bromide In water; chlorobenzene at 60℃; for 72h;95%
With tetrabutylammomium bromide In water; chlorobenzene54%
Stage #1: [3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-phenyl]-methanol With sodium hydride In tetrahydrofuran at 0℃; for 0.0833333h; Inert atmosphere;
Stage #2: anthracenylmethyl chloride In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester
709656-07-5

2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

4-(anthracen-9-ylmethyl)-2-phenyl-1,3-oxazoline-4-carboxylic acid tert-butyl ester

4-(anthracen-9-ylmethyl)-2-phenyl-1,3-oxazoline-4-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With potassium hydroxide; tetrabutylammomium bromide In toluene at 25℃; for 0.5h;95%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

3-Mercaptopropyltriethoxysilane
14814-09-6

3-Mercaptopropyltriethoxysilane

3-[(anthracen-10-yl)methylthio]propyltriethoxysilane
1239599-24-6

3-[(anthracen-10-yl)methylthio]propyltriethoxysilane

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Reflux;95%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

sodium acetate
127-09-3

sodium acetate

(anthracen-9-yl)methyl acetate
16430-32-3

(anthracen-9-yl)methyl acetate

Conditions
ConditionsYield
In ethanol at 50℃; for 6h;95%
phenyl selenocyanate
2179-79-5

phenyl selenocyanate

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

9-anthrylmethyl phenyl selenide
78808-34-1

9-anthrylmethyl phenyl selenide

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol for 5h; Heating;94%
potassium cyanide

potassium cyanide

anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

anthracen-9-yl-acetonitrile
2961-76-4

anthracen-9-yl-acetonitrile

Conditions
ConditionsYield
In water; dimethyl sulfoxide at 60℃; for 1h;94%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

(1R,5S)-1,8,8-trimethyl-4-(o-tolyl)-2,4-diazabicyclo[3.2.1]oct-2-ene

(1R,5S)-1,8,8-trimethyl-4-(o-tolyl)-2,4-diazabicyclo[3.2.1]oct-2-ene

(1R,5S)-2-(anthracen-9-ylmethyl)-1,8,8-trimethyl-4-(o-tolyl)-2,4-diazabicyclo[3.2.1]oct-2-en-2-ium chloride

(1R,5S)-2-(anthracen-9-ylmethyl)-1,8,8-trimethyl-4-(o-tolyl)-2,4-diazabicyclo[3.2.1]oct-2-en-2-ium chloride

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide; acetonitrile for 16h; Reflux; Schlenk technique;94%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

2,6-bis(selenocyanatomethyl)pyridine
85539-82-8

2,6-bis(selenocyanatomethyl)pyridine

2,6-bis[(selenomethylanthryl)methyl]pyridine

2,6-bis[(selenomethylanthryl)methyl]pyridine

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; ethanol for 24h; reductive alkylation;93%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

1-carbomethoxy-3,5-dihydroxybenzene
2150-44-9

1-carbomethoxy-3,5-dihydroxybenzene

methyl 3,5-bis(anthrylmethoxy)benzoate
540781-07-5

methyl 3,5-bis(anthrylmethoxy)benzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 3h;93%
anthracenylmethyl chloride
24463-19-2

anthracenylmethyl chloride

1-aza-4,10-dithia-7‐oxacyclododecane
24918-63-6

1-aza-4,10-dithia-7‐oxacyclododecane

1-(9-anthracenylmethyl)-1-aza-4,10-dithia-7-oxacyclododecane
1243242-53-6

1-(9-anthracenylmethyl)-1-aza-4,10-dithia-7-oxacyclododecane

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 168h; Inert atmosphere;93%

24463-19-2Relevant articles and documents

Anthracene coupled adenine for the selective sensing of copper ions

Ghosh, Kumaresh,Sen, Tanushree

, (2010)

Anthracene-based adenines 1 and 2 have been designed and synthesized, and their metal ion recognition properties have been established fluorometrically. Both molecules exhibit Cu 2+ induced ON-OFF type signaling patterns over the other representative metal ions studied. Compound 1 exhibits 97% quenching of emission in the presence of Cu 2+ whilst derivative 2 shows 81% quenching under similar experimental conditions.

Intramolecular stacking of two aromatic rings in the platinum(II) coordination sphere: Preparation, crystal structures, and 1H NMR spectra of bipyridine(N-arylmethyl-1,2-ethanediamine)platinum(II) nitrate

Goto, Masafumi,Matsumoto, Takashi,Sumimoto, Masamitsu,Kurosaki, Hiromasa

, p. 97 - 105 (2000)

Square-planar complexes with the formula [Pt(L1)(L2)](NO3)2·nH2O, where L1 is bipyridine (bpy) and L2 is N-benzyl-1,2-ethanediamine (Been) (1) (n = 0), N-(1-naphthyl)methyl-1,2-ethanediamine (Npen) (2) (n = 2), and N-(9-anthryl)methyl-1,2-ethanediamine (Aten) (3) (n = 2), were prepared and X-ray crystal-structure determinations were carried out. The molecular structures of the complex cations revealed that the N-arylmethyl groups are forced to take pseudo axial dispositions due to an intramolecular repulsion from hydrogen atoms of bpy. The aromatic-aromatic interaction between the aromatic rings of ethanediamine derivatives and coordinated bpy caused 2 and 3 to take a conformation where the aromatic ring and bpy stack face-to-face to each other intramolecularly. An intermolecular aromatic-aromatic face-to- face interaction was also observed for 1, 2, and 3 in the crystals. The latter interaction occurs between bpy and the aryl substituent, except for 1. For D2O solutions of 1 through 3, significant upfield shifts due to the intramolecular stacking were observed in the 1H NMR spectra for the protons on the half ring of bipyridine, depending on the size of the aromatic ring. The crystal data of 1: monoclinic, P21/c, a = 9.884(2), b = 24.717(2), c = 9.560(5) A, β = 113.83(3)°, Z = 4, and R = 0.029. 2: monoclinic, Ia, a = 17.030(5), b = 10.461(4), c = 14.727(4) A, β = 94.72°, Z = 4, and R = 0.023. 3: monoclinic, P(n), a = 10.471(2), b = 8,844(5), c = 15.332(3)A, β = 98.61(2)°, Z = 2, and R = 0.034.

Reductive Amination by Photoredox Catalysis and Polarity-Matched Hydrogen Atom Transfer

Guo, Xingwei,Wenger, Oliver S.

supporting information, p. 2469 - 2473 (2018/01/27)

The excitation of a RuII photosensitizer in the presence of ascorbic acid leads to the reduction of iminium ions to electron-rich α-aminoalkyl radical intermediates, which are rapidly converted into reductive amination products by thiol-mediated hydrogen atom transfer (HAT). As a result, the reductive amination of carbonyl compounds with amines by photoredox catalysis proceeds in good to excellent yields and with broad substrate scope and good functional group tolerance. The three key features of this work are 1) the rapid interception of electron-rich α-aminoalkyl radical intermediates by polarity-matched HAT in a photoredox reaction, 2) the method of reductive amination by photoredox catalysis itself, and 3) the application of this new method for temporally and spatially controlled reactions on a solid support, as demonstrated by the attachment of a fluorescent dye on an activated cellulose support by photoredox-catalyzed reductive amination.

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