2450-53-5 Usage
Description
Isochlorogenic acid A, also known as 3,5-Dicaffeoylquinic acid (3,5-DCQA), is a natural phenolic compound found in various plants such as L. japonica and I. kaushue. It exhibits antioxidant, anti-inflammatory, and antiviral properties, making it a promising candidate for various applications in the pharmaceutical and healthcare industries.
Uses
Used in Antioxidant Applications:
Isochlorogenic acid A is used as an antioxidant agent for its ability to protect cells against oxidative stress. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in a cell-free assay and inhibits superoxide production in human neutrophils, demonstrating its potential in combating oxidative damage.
Used in DNA Protection:
Isochlorogenic acid A is used as a DNA protective agent due to its ability to inhibit HIV-1 integrase 3''-end processing, strand transfer, and disintegration in a cell-free assay. This suggests its potential role in protecting DNA from viral integration and subsequent damage.
Used in Anti-inflammatory Applications:
Isochlorogenic acid A is used as an anti-inflammatory agent for its ability to inhibit the production of superoxide in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B. This property makes it a potential candidate for treating inflammation-related conditions.
Used in Antiviral Applications:
Isochlorogenic acid A is used as an antiviral agent, particularly against HIV-1. It inhibits HIV-1-induced cytotoxicity in MT-2 cells and protects mice from acute lung injury induced by LPS, suggesting its potential in treating viral infections and their associated complications.
Used in Pharmaceutical Industry:
Isochlorogenic acid A is used in the pharmaceutical industry for its diverse biological activities, including antioxidant, anti-inflammatory, and antiviral properties. Its potential applications in this industry range from the development of novel drugs to the enhancement of existing treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 2450-53-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,5 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2450-53:
(6*2)+(5*4)+(4*5)+(3*0)+(2*5)+(1*3)=65
65 % 10 = 5
So 2450-53-5 is a valid CAS Registry Number.
InChI:InChI=1/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(30)36-19-11-25(35,24(33)34)12-20(23(19)32)37-22(31)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-29,32,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23-,25+/m1/s1
2450-53-5Relevant articles and documents
Total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives
Raheem, K. Saki,Botting, Nigel P.,Williamson, Gary,Barron, Denis
, p. 7175 - 7177 (2012/01/05)
We report the first total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives, 3,5-O-diferuloylquinic acid and 3,5-(3,4-dimethoxycinnamyl)quinic acid, in a nine-step sequence. The key step involves Knoevenagel condensations between vanillin, 3,4-dimethoxybenzaldehyde or 4-hydroxy-3-methoxybenzaldehyde and the dimalonate ester of quinic acid.
