24515-53-5

Basic information

• Product Name: ethyl N-chloroacetylsarcosinate
• Synonyms: ethyl N-chloroacetylsarcosinate;Glycine, N-(chloroacetyl)-N-methyl-, ethyl ester;ethyl N-(2-chloroacetyl)-N-methylglycinate
• CAS NO: 24515-53-5
• Molecular Formula: C₇H₁₂ClNO₃
• Molecular Weight: 193.62808
• Mol File: 24515-53-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl N-chloroacetylsarcosinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-chloroacetylsarcosinate(24515-53-5)
• EPA Substance Registry System: ethyl N-chloroacetylsarcosinate(24515-53-5)

Safety Data

• Hazardous Substances Data: 24515-53-5(Hazardous Substances Data)

Usage

General Description

Ethyl N-chloroacetylsarcosinate, also known as Chloroacetylsarcosinamate, is a chemical compound with the molecular formula C7H12ClNO3. It is a derivative of sarcosine, an amino acid, and contains a chloroacetyl group. This chemical is commonly used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is known for its ability to undergo reactions such as esterification, amidation, and nucleophilic substitution. Ethyl N-chloroacetylsarcosinate is a versatile compound and is used as a building block for the synthesis of various biologically active molecules. Its applications range from drug synthesis to materials science. Additionally, it is important to handle this chemical with caution, as it is a potential irritant and can cause skin and eye irritation if not handled properly.

Upstream product

• 13200-60-7 Sarcosine ethyl ester 
• 79-04-9 chloroacetyl chloride 
• 52605-49-9 sarcosine ethyl ester hydrochloride 

Downstream Products

• 1261491-89-7 2-((2-ethoxy-2-oxoethyl)(methylamino)-2-oxoethyl 5-tetradecyloxy)furan-2-carboxylate 
• 116482-77-0 2-Acetoxy-benzoic acid (ethoxycarbonylmethyl-methyl-carbamoyl)-methyl ester 
• 106231-63-4 2-(benzoyloxy)-(N-methyl-N-ethoxycarbonylmethyl)acetamide 
• 5625-52-5 1-methylpiperazin-2,5-dione 

Relevant articles and documents

PYRROLE DERIVATIVES AS ACC INHIBITORS

Novel pyrrole derivatives of Formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Acetyl- CoA carboxylase (ACC).

PRODRUGS OF LANICEMINE AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention include substituted Lanicemine prodrugs useful for the treatment of conditions associated with dysregulation of NMDA receptor activity such as depression and depressive disordersthrough the release of Lanicemine, Prodrugs of Lanicemine have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release Lanicemine in the plasma via either an enzymatic or general biophysical release process.

Olumacostat glasaretil

Acne vulgaris is a common dermatologic condition affecting adolescents and adults. Systemic and topical therapies have been developed to target different mechanisms in the pathogenesis of acne. Olumacostat glasaretil (OG) is a novel topical agent that targets sebum production in the treatment of acne vulgaris. OG’s active metabolite acts as a competitive inhibitor of the rate-limiting enzyme of fatty acid synthesis, acetyl-coenzyme A (CoA) carboxylase (ACC). ACC catalyzes malonyl-CoA formation and sebum production. OG is efficacious in the treatment of acne vulgaris and has a low side effect profile. Phase IIa and IIb trials note side effects including application-site erythema and dryness, and nasopharyngitis. Phase III trials are currently underway. The new mechanism of action of OG is sensible, attractive and exciting, but the available data do not demonstrate that it provides a quantum leap forward over existing therapies.