245328-53-4Relevant articles and documents
Spiroheterocycles from reaction of nitrones with methylene-γ-butyrolactones and some of their rearrangements
Roussel, Christophe,Fihi, Rachid,Ciamala, Kabula,Vebrel, Joel,Zair, Touria,Riche, Claude
, p. 2689 - 2698 (2003)
Cycloaddition of nitrones 1 with methylene-γ-butyrolactones 2, 3 and 4 afforded spiroadducts 5, 6 and 7 with high selectivity. Mixtures of diastereoisomers were usually obtained, whose structures were established by 1H and 13C NMR spectroscopies or X-ray crystallography. Treatment of spiroadducts in acidic and alkaline media led to different, unexpected and novel rearrangements.
Preparation of 2-pyridone-containing tricyclic alkaloid derivatives as potential inhibitors of tumor cell proliferation by regioselective intramolecular N- and C-acylation of 2-pyridone
Wang, Shaozhong,Cao, Liya,Shi, Haijian,Dong, Yanmei,Sun, Jianwei,Hu, Yuefei
, p. 67 - 71 (2007/10/03)
A novel and practical preparation of 2-pyridone-containing tricyclic alkaloid derivatives was developed. By regioselective intramolecular N- and C-acylation of 2-(4-aryl-2-pyridon-6-yl)benzoic acid, a pair of structural isomers 2-aryl pyrido[2,1-a]isoindo