245408-81-5

Basic information

• Product Name: 3-[2-(benzoyloxy)ethyl]-2,2-dichlorocyclobutanone
• Synonyms: 3-[2-(benzoyloxy)ethyl]-2,2-dichlorocyclobutanone
• CAS NO: 245408-81-5
• Molecular Weight: 287.142
• Mol File: 245408-81-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-[2-(benzoyloxy)ethyl]-2,2-dichlorocyclobutanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(benzoyloxy)ethyl]-2,2-dichlorocyclobutanone(245408-81-5)
• EPA Substance Registry System: 3-[2-(benzoyloxy)ethyl]-2,2-dichlorocyclobutanone(245408-81-5)

Safety Data

• Hazardous Substances Data: 245408-81-5(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 18203-32-2 3-butenyl benzoate 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 18203-32-2 3-butenyl benzoate 

Relevant articles and documents

MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS

Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

Photocycloelimination of α,α-dichlorocyclobutanones

Direct irradiation of a series of α,α-dichlorocyclobutanones in benzene solutions results in photocycloelimination to give 1,1-dichloroalkenes in yields ranging from 30-65%. The α,α-dichlorocyclobutanones were formed in good yields from the [2+2] cycloaddition of the terminal olefins with dichloroketene. This two-step sequence formally represents a "metathesis" of two olefinic functions and provides an easy access to functionalized 1,1-dichloroalkenes. Irradiation of the dichlorocyclobutanones in the solid state led to poor yields of 1,1-dichloroalkenes and polymeric mixtures, however, photoreactions performed in zeolites gave similar yields as those run in benzene solutions.