24629-25-2

Basic information

• Product Name: L-(+)-Isoleucinol
• Synonyms: (2S,3S)-2-AMINO-3-METHYL-PENTAN-1-OL;(2S,3S)-2-AMINO-3-METHYL-1-PENTANOL;2-AMINO-3-METHYL-1-PENTANOL;(+)-L-ISOLEUCINOL;L(+)-ISOLEUCINOL;L-ISOLEUCINOL;H-ILE-OL;H-L-ILE-OL
• CAS NO: 24629-25-2
• Molecular Formula: C₆H₁₅NO
• Molecular Weight: 117.19
• EINECS: 246-371-4
• Product Categories: Pharmaceutical Intermediates;Amines;blocks;Amino Alcohols;Isoleucine [Ile, I];Amino Alcohols (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound;Amino alcohols
• Mol File: 24629-25-2.mol
• Article Data: 27

Chemical Properties

• Melting Point: 36-39 °C(lit.)
• Boiling Point: 97 °C14 mm Hg(lit.)
• Flash Point: 213 °F
• Appearance: White to light yellow/Viscous Liquid
• Density: 0.9490 (rough estimate)
• Vapor Pressure: 0.0998mmHg at 25°C
• Refractive Index: n20/D 1.4589(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 12.88±0.10(Predicted)
• CAS DataBase Reference: L-(+)-Isoleucinol(CAS DataBase Reference)
• NIST Chemistry Reference: L-(+)-Isoleucinol(24629-25-2)
• EPA Substance Registry System: L-(+)-Isoleucinol(24629-25-2)

Safety Data

• Hazard Codes: C,Xi,Xn
• Statements: 34-22-40
• Safety Statements: 45-36/37/39-26-36-22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 24629-25-2(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystalline solid or

InChI:InChI=1/C6H15NO/c1-3-5(2)6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/p+1/t5-,6+/m0/s1

Upstream product

• 73-32-5 DL-isoleucine 
• 2577-46-0 L-isoleucine methyl ester 
• 921-74-4 L-isoleucine ethyl ester 
• 73-32-5 L-isoleucine 
• 73-32-5 L-isoleucine 
• 1044283-23-9 C₇H₁₅NO₃*C₁₂H₂₆N₂ 
• 911672-00-9 N-(N-benzoyl-glycyl)-L-isoleucine ethyl ester 

Downstream Products

• 108915-03-3 (4S)-4-<(S)-1-Methylpropyl>-2-(2-pyridinyl)-2-oxazolin 
• 131380-81-9 1,2-Bis<(4S)-4-<(1S)-1-methylpropyl>-2-oxazolin-2-yl>benzene 
• 85711-06-4 (2S,3S)-2-Dimethylamino-3-methyl-pentan-1-ol 
• 220306-87-6 N-((1S,2S)-1-Hydroxymethyl-2-methyl-butyl)-4-methoxy-2,3,6-trimethyl-benzenesulfonamide 
• 289719-34-2 (2S,3S)-2-((2S,3S)-2-Dibenzylamino-3-methyl-pentylamino)-3-methyl-pentan-1-ol 
• 462102-43-8 (2S,3S)-2-[(4-dimethylamino-benzylidene)-amino]-3-methyl-penan-1-ol 
• 857040-99-4 (2S,2S)-2-(2-chloro-3-nitrobenzylamino)-3-methylpentan-1-ol 
• 635291-27-9 4-Iodo-N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide 
• 1054529-25-7 C₁₂H₁₇ClFNO₃S 
• 1054529-34-8 C₁₃H₁₈ClNO₂ 
• 1242079-41-9 1,3,5-tris[(S,S)-4-(1-hydroxymethyl-2-methylbutyliminomethyl)benzyloxycarbonyl]benzene 
• 1242079-46-4 1,3,5-tris[(S,S)-4-(1-hydroxymethyl-2-methylbutylaminomethyl)benzyloxycarbonyl]benzene 

Relevant articles and documents

Chiral enantiopure organosilane precursors for the synthesis of periodic mesoporous organosilicas

The manuscript describes synthesis of new chiral organosilica networks starting from modified readily available enantiopure substances such as sugars and amino acids. We report on the successful preparation of robust all-chiral organosilicas by polymerization of the homochiral monomers. When the homochiral organosilane monomers were polymerized in mixtures of polar organic solvents and water in the presence of hydrochloric acid or tetrabutylammonium fluoride as catalysts, mainly spherical microparticles were obtained due to emulsification of the hydrophobic monomers in these mixtures. Polycondensation of the chiral organosilanes in the presence of Pluronic P123 as a template produced ordered mesoporous networks. The new all-chiral materials were characterized by SEM, STEM, BET, SAXS, IR, NMR and TGA.

Selective hydrogenation of primary amides and cyclic di-peptides under Ru-catalysis

A ruthenium(II)-catalyzed selective hydrogenation of challenging primary amides and cyclic di-peptides to their corresponding primary alcohols and amino alcohols, respectively, is reported. The hydrogenation reaction operates under mild and eco-benign conditions and can be scaled-up.

Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type ring opening followed by cyclization of the resulting haloalkoxy amine.