24654-08-8

Basic information

• Product Name: 3-(2-chlorophenyl)prop-2-ynoic acid
• Synonyms: 2-propynoic acid, 3-(2-chlorophenyl)-
• CAS NO: 24654-08-8
• Molecular Formula: C₉H₅ClO₂
• Molecular Weight: 180.5878
• Mol File: 24654-08-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 340.3°C at 760 mmHg
• Flash Point: 159.6°C
• Density: 1.4g/cm³
• Vapor Pressure: 3.36E-05mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 3-(2-chlorophenyl)prop-2-ynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)prop-2-ynoic acid(24654-08-8)
• EPA Substance Registry System: 3-(2-chlorophenyl)prop-2-ynoic acid(24654-08-8)

Safety Data

• Hazardous Substances Data: 24654-08-8(Hazardous Substances Data)

Usage

General Description

3-(2-chlorophenyl)prop-2-ynoic acid is a chemical compound with the molecular formula C9H5ClO2. It is a derivative of propiolic acid and contains a chlorophenyl group. 3-(2-chlorophenyl)prop-2-ynoic acid is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in organic and synthetic chemistry research as a building block for various chemical reactions. Its properties and reactivity make it an important intermediate in the production of a wide range of chemical products.

Upstream product

• 86461-84-9 5-[1,2-Dibromo-2-(2-chloro-phenyl)-ethyl]-3-methyl-4-nitro-isoxazole 
• 124-38-9 carbon dioxide 
• 401514-40-7 1-chloro-2-(2,2-dibromovinyl)benzene 
• 42174-97-0 3-(2-chloro-phenyl)-acrylic acid methyl ester 
• 3752-25-8 o-chlorocinnamic acid 
• 873-31-4 2-chlorophenylacetylene 
• 609-65-4 o-chlorobenzoyl chloride 
• 89-98-5 2-chloro-benzaldehyde 
• 704-96-1 trans-2-chlorocinnamic acid 
• 75143-77-0 3-methyl-4-nitro-5-(2-chlorostyryl)isoxazole 
• 7517-81-9 methyl 3-(2-chlorophenyl)propiolate 
• 96277-01-9 methyl 3-(2-chlorophenyl)-3-oxo-2-(triphenylphosphoranylidene)propanoate 
• 24654-09-9 ethyl 3-(2-chlorophenyl)prop-2-ynoate 
• 24393-51-9 (E)-ethyl 2-chlorocinnamate 

Downstream Products

• 841205-66-1 (2-chlorophenyl)propynoic acid prop-2-ynyl ester 
• 1355094-04-0 (E)-2-(2-chlorostyryl)-4,4,5,5-tetramethyl-1,3-dioxa-2-borolane 
• 103261-03-6 2-(2-chlorophenyl)-2-oxoethyl acetate 
• 135595-17-4 4-(2-chloro-phenyl)-4-oxo-butyronitrile 
• 153686-97-6 1-(2-chloro-phenyl)-pentane-1,4-dione 

Relevant articles and documents

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Organocatalytic Strategy for the Fixation of CO2via Carboxylation of Terminal Alkynes

An organocatalytic strategy for the direct carboxylation of terminal alkynes with CO2 has been developed. The combined use of a bifunctional organocatalyst and Cs2CO3 resulted in a robust catalytic system for the preparation of a range of propiolic acid derivatives in high yields with broad substrate scope using CO2 at atmospheric pressure under mild temperatures (60 °C). This work has demonstrated that this organocatalytic method offers a competitive alternative to metal catalysis for the carboxylation of terminal alkynes and CO2. In addition, this protocol was suitable for the three-component carboxylation of terminal alkynes, alkyl halides, and CO2.

Synthesis and antibacterial evaluation of novel 11-O-aralkylcarbamoyl-3-O-descladinosylclarithromycin derivatives

A series of novel 11-O-aralkylcarbamoyl-3-O-descladinosylclarithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activity. The results showed that the majority of the target compounds displayed potent activity against erythromycin-susceptible S. pyogenes, erythromycin-resistant S. pneumoniae A22072 expressing the mef gene and S. pneumoniae AB11 expressing the mef and erm genes. Besides, most of the target compounds exhibited moderate activity against erythromycin-susceptible S. aureus ATCC25923 and B. subtilis ATCC9372. In particular, compounds 11a, 11b, 11c, 11e, 11f and 11h were found to exert favorable antibacterial activity against erythromycin-susceptible S. pyogenes with the MIC values of 0.015–0.125 μg/mL. Furthermore, compounds 10e, 11a, 11b and 11c showed superior activity against erythromycin-resistant S. pneumoniae A22072 with the MIC values of 0.25–0.5 μg/mL. Additionally, compound 11c was the most effective against all the erythromycin-resistant S. pneumoniae strains (A22072, B1 and AB11), exhibiting 8-, 8- and 32-fold more potent activity than clarithromycin, respectively.