247037-77-0

Basic information

• Product Name: methyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
• Synonyms: methyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate;EOS-60667
• CAS NO: 247037-77-0
• Molecular Formula: C₁₆H₁₃ClFN₃O₂S
• Molecular Weight: 365.8097232
• Mol File: 247037-77-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate(247037-77-0)
• EPA Substance Registry System: methyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate(247037-77-0)

Safety Data

• Hazardous Substances Data: 247037-77-0(Hazardous Substances Data)

Upstream product

• 298709-35-0 methyl 2-(2-chloro-4-fluorobenzylidene)-3-oxobutanoate 
• 247037-82-7 1,3-thiazole-2-carboximidamide hydrochloride 
• 67-56-1 methanol 
• 30414-53-0 methyl propanoyl acetate 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 84194-30-9 2-chloro-5-fluorobenzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 1571212-55-9 (3S)-4-((6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidine-4-yl)methyl)morpholine-3-carboxylic acid 
• 1578155-50-6 (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)-3-methylmorpholine-3-carboxylic acid 

Relevant articles and documents

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

Provided are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.

HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

Thiazolyl dihydropyrimidine compound as well as preparation method and application thereof

The invention provides a thiazolyl dihydropyrimidine compound shown in a formula (I) as shown in the description or pharmaceutical salt, or a tautomer, or an enantiomer, or a diastereoisomer thereof,wherein R1, R2, R3, m, n and A are defined in the specification and claims. The invention also provides a preparation method of the compound shown in the formula (I) and medicinal application of the compound in treatment or prevention of hepatitis B virus infection.