247564-55-2

Basic information

• Product Name: 4,7-DIFLUOROINDOLE
• Synonyms: 4,7-DIFLUOROINDOLE;1H-Indole,4,7-difluoro-(9CI);4,7-Difluoro-1H-indole;1H-Indole, 4,7-difluoro-;4,7-difluoroiindole
• CAS NO: 247564-55-2
• Molecular Formula: C8H5F2N
• Molecular Weight: 153.13
• EINECS: 200-258-5
• Product Categories: HALIDE;INDOLE;Indole/indoline/oxindole;Indoles
• Mol File: 247564-55-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 261 °C at 760 mmHg
• Flash Point: 111.7 °C
• Appearance: /
• Density: 1.388 g/cm³
• Vapor Pressure: 0.0192mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: 2-8°C
• PKA: 14.95±0.30(Predicted)
• CAS DataBase Reference: 4,7-DIFLUOROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-DIFLUOROINDOLE(247564-55-2)
• EPA Substance Registry System: 4,7-DIFLUOROINDOLE(247564-55-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 247564-55-2(Hazardous Substances Data)

Usage

General Description

4,7-DIFLUOROINDOLE is a chemical compound that belongs to the class of organic compounds known as indoles, which are aromatic heterocyclic organic compounds. It is characterized by the presence of two fluorine atoms at positions 4 and 7 on the indole ring. 4,7-DIFLUOROINDOLE is commonly used as a building block for the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential biological activities, including its role as a potential anti-cancer agent and as a fluorescent probe for detecting hydrogen peroxide in living cells. 4,7-DIFLUOROINDOLE has also been investigated as a precursor for the preparation of fluorescent polymers and for use in materials science.

InChI:InChI=1/C8H5F2N/c9-6-1-2-7(10)8-5(6)3-4-11-8/h1-4,11H

Upstream product

• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 1393735-83-5 N-(6-nitroveratryloxycarbonyl)-4,7-difluorotryptophan cyanomethyl ester 

Relevant articles and documents

Ondansetron and granisetron binding orientation in the 5-HT3 receptor determined by unnatural amino acid mutagenesis

The serotonin type 3 receptor (5-HT3R) is a ligand-gated ion channel found in the central and peripheral nervous systems. The 5-HT 3R is a therapeutic target, and the clinically available drugs ondansetron and granisetron inhibit receptor activity. Their inhibitory action is through competitive binding to the native ligand binding site, although the binding orientation of the drugs at the receptor has been a matter of debate. Here we heterologously express mouse 5-HT3A receptors in Xenopus oocytes and use unnatural amino acid mutagenesis to establish a cation-π interaction for both ondansetron and granisetron to tryptophan 183 in the ligand binding pocket. This cation-π interaction establishes a binding orientation for both ondansetron and granisetron within the binding pocket.

PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS

The present invention relates to a compound of the formula (I), or a pharmaceutically acceptable salt thereof, wherein R1-R8 and X, m, and n are defined. Compounds and compositions of the present invention are useful the treatment of atherosclerosis.