248263-04-9

Basic information

• Product Name: [1,1'-BIPHENYL]-4-CARBOXALDEHYDE,2-METHOXY-
• Synonyms: [1,1'-BIPHENYL]-4-CARBOXALDEHYDE,2-METHOXY-;3-methoxy-4-phenylbenzaldehyde
• CAS NO: 248263-04-9
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Mol File: 248263-04-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1,1'-BIPHENYL]-4-CARBOXALDEHYDE,2-METHOXY-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-BIPHENYL]-4-CARBOXALDEHYDE,2-METHOXY-(248263-04-9)
• EPA Substance Registry System: [1,1'-BIPHENYL]-4-CARBOXALDEHYDE,2-METHOXY-(248263-04-9)

Safety Data

• Hazardous Substances Data: 248263-04-9(Hazardous Substances Data)

Usage

General Description

[1,1'-BIPHENYL]-4-CARBOXALDEHYDE,2-METHOXY- is a chemical compound with the molecular formula C15H12O2. It is a derivative of biphenyl and contains a carboxaldehyde group and a methoxy group. [1,1'-BIPHENYL]-4-CARBOXALDEHYDE,2-METHOXY- is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and dyes. Its aromatic structure and functional groups make it a versatile compound for use in the production of diverse chemical products. Additionally, it has been studied for its potential biological activities and is a subject of interest in medicinal chemistry research.

Upstream product

• 25649-41-6 4,4',4''-((1,3,5-triazine-2,4,6-triyl)tris(oxy))tris(3-methoxybenzaldehyde) 
• 98-80-6 phenylboronic acid 
• 1432754-86-3 4-((4,6-dimethoxy-1,3,5-triazin-2-yl)oxy)-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 52200-05-2 4-methanesulfonyloxy-3-methoxybenzaldehyde 
• 194018-68-3 vanillin triflate 
• 246224-09-9 4-formyl-2-methoxyphenyl-1-(4-methylbenzenesulfonate) 

Downstream Products

• 858674-11-0 3-hydroxy-4-phenylbenzaldehyde 

Relevant articles and documents

A novel anti-Alzheimer agent inhibiting oligomerization and fibriliation of beta-amyloid protects neuronal cell from Aβ-induced cytotoxicity

The present invention relates to development of a novel treatment agent for Alzheimerandprime;s disease, having ability of protecting neural cells and inhibiting fibrosis and oligomerization of beta-amyloid. A compound of the present invention is capable of, while maintaining therapeutic effects on Alzheimerandprime;s disease, recovering ability of directly inhibiting oligomerized and fibrous amyloid beta, which is inherent activities of existing curcumin, thereby being useful as a novel inhibitor.COPYRIGHT KIPO 2017

Nickel-catalyzed one-pot synthesis of biaryls from phenols and arylboronic acids via C-O activation using TCT reagent

In this study, the direct Nickel-catalyzed Suzuki-Miyaura coupling reaction of phenols and arylboronic acids via C-O bond activation using 2,4,6-trichloro-1,3,5-triazine (TCT) is described. Initially, phenols were reacted with TCT to give the corresponding 2,4,6-triaryloxy-1,3,5-triazine (TAT) products. Subsequently, arylboronic acid, base and Ni-catalyst were added to the generated aryl C-O electrophile to obtain the final biaryl product. This study represents a simple and direct method for the synthesis of biaryls from phenolic compounds using sub-stoichiometric amounts of TCT as a cheap and readily available C-O activating reagent.

Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids

Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5- triazine-6-yl ethers, in which aryl C-O bond could be selectively cleaved with inexpensive, air-stable NiCl2(dppf) as a catalyst. Coupling of these readily accessible heteroaryl ethers proved tolerant of extensive functional groups.