2486-80-8

Basic information

• Product Name: 4-AMINO-2-METHOXYBENZOIC ACID
• Synonyms: 4-AMINO-2-METHOXYBENZENECARBOXYLIC ACID;4-AMINO-2-METHOXYBENZOIC ACID;2-METHOXY-4-AMINO-BENZOIC ACID;4-amino-o-anisic acid;4-azanyl-2-methoxy-benzoic acid;NSC 208766;4-Amino-o-anisic acid, 4-Carboxy-3-methoxyaniline;4-Amino-2-methoxybenzoic acid 97%
• CAS NO: 2486-80-8
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• EINECS: 219-632-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatics Compounds;Aromatics;Aromatic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 2486-80-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 149-153 °C(lit.)
• Boiling Point: 365.9 °C at 760 mmHg
• Flash Point: 175.1 °C
• Appearance: Yellow crystalline solid
• Density: 1.303 g/cm³
• Vapor Pressure: 5.37E-06mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 4.75±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-2-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-METHOXYBENZOIC ACID(2486-80-8)
• EPA Substance Registry System: 4-AMINO-2-METHOXYBENZOIC ACID(2486-80-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2486-80-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Crystalline Solid

Uses

2-Methoxy-4-aminobenzoic Acid (cas# 2486-80-8) is a compound useful in organic synthesis.

InChI:InChI=1/C8H9NO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4H,9H2,1H3,(H,10,11)

Upstream product

• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 4093-29-2 methyl 4-(acetylamino)-o-anisate 
• 6059-17-2 ethyl 4-amino-2-hydroxybenzoate 
• 22776-13-2 ethyl 4-acetylamino-o-hydroxybenzoate 
• 65-49-6 4-Aminosalicylic acid 
• 5428-54-6 2-methyl-5-nitrophenol 
• 101084-96-2 2-methoxy-4-nitrobenzonitrile 
• 579-75-9 2-Methoxybenzoic acid 
• 1134-65-2 2-methoxy-4-acetyl-amino-benzaldehyde 
• 2597-56-0 4-nitro-o-anisic acid 
• 55304-05-7 4-acetylamino-2-methoxy-benzoic acid 
• 39106-79-1 methyl 2-methoxy-4-nitrobenzoate 

Downstream Products

• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 89469-52-3 2-methoxy-4-cyano-benzoic acid 
• 93078-55-8 (carboxy-4-methoxy-3-phenyl)-1-methyl-2-(cyclohexul-4-phenyl)-5-pyrrole 
• 89469-32-9 4-Chlorosulphonyl-2-methoxybenzoic acid 
• 102362-19-6 4-azido-2-methoxybenzoic acid 
• 168914-46-3 2-(1-Piperidinyl)ethyl 4-amino-2-methoxybenzoate 
• 55304-05-7 4-acetylamino-2-methoxy-benzoic acid 
• 176849-91-5 4-amino-N-(1-ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide 
• 102362-21-0 4'-azido-2'-methoxyacetophenone 
• 102362-22-1 2-bromo-4'-azido-2'-methoxyacetophenone 
• 102362-20-9 4-azido-2-methoxybenzoyl chloride 
• 102362-24-3 2-(4-amino-2-methoxyphenyl)imidazo<1,2-a>pyrimidine 
• 102361-86-4 2-(2-methoxy-4-methylsulphonylaminophenyl)imidazo<1,2-a>pyrimidine 

Relevant articles and documents

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Salicylic-acid derivatives as antennae for ratiometric luminescent probes based on lanthanide complexes

Long-lived ratiometric sensors: Luminescent lanthanide complexes are widely used in time-resolved assays of biomolecules, but most of the sensors with these complexes rely on single-point intensity measurements. Herein, we introduce a simple strategy to create ratiometric probes by using salicylic-acid derivatives as the antenna moiety of Tb3+ complexes. As an example, a probe for alkaline phosphatase (ALP) was developed (see scheme). Copyright

Indole-type derivatives as inhibitors of p38 kinase

The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which is an amino or substituted amino group.