2487-40-3

Basic information

• Product Name: 2-Thioxanthine
• Synonyms: 1,2,3,7-tetrahydro-2-thioxo-6h-purin-6-on;1,2,3,7-Tetrahydro-2-thioxo-6H-purin-6-one;2-Sulfanyl-9H-purin-6-ol;2-thioxanthene;2-thio-xanthin;6H-Purin-6-one, 1,2,3,7-tetrahydro-2-thioxo-;Xanthine, 2-thio-;6-HYDROXY-2-MERCAPTOPURINE
• CAS NO: 2487-40-3
• Molecular Formula: C₅H₄N₄OS
• Molecular Weight: 168.18
• EINECS: 219-636-7
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents
• Mol File: 2487-40-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: >300°C
• Appearance: /
• Density: 1.534 (estimate)
• Refractive Index: 1.6390 (estimate)
• PKA: 9.28±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Thioxanthine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thioxanthine(2487-40-3)
• EPA Substance Registry System: 2-Thioxanthine(2487-40-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• RTECS: UP0825000
• TSCA: Yes
• Hazardous Substances Data: 2487-40-3(Hazardous Substances Data)

Usage

Uses

2-Thioxanthine used to inhibit MPO (Myeloperoxidase).

InChI:InChI=1/C5H4N4OS/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1-2H,(H2,6,7,8,9,10,11)

Upstream product

• 1004-40-6 6-Amino-2-thiouracil 
• 117043-67-1 5,6-diamino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one; sulfate 
• 77287-34-4 formamide 
• 64194-62-3 N-(4-amino-2-mercapto-6-oxo-1,6-dihydropyrimidin-5-yl) formamide 
• 64194-62-3 4-amino-5-formamido-6-hydroxy-2-mercaptopyrimidine 
• 72-40-2 5-aminoimidazole-4-carboxamide hydrochloride 
• 103-72-0 phenyl isothiocyanate 
• 1004-76-8 4,5-diamino-6-hydroxy-2-thiopyrimidine 
• 140-89-6 potassium ethyl xanthogenate 
• 72-40-2 5-amino-1H-imidazole-4-carboxamide monohydrochloride 
• 1004-76-8 5,6-diamino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 

Downstream Products

• 5446-89-9 2-methylsulfanyl-1,7⁽⁹⁾-dihydro-purin-6-one 
• 87781-93-9 2-bromo-6-hydroxypurine 
• 5752-57-8 2-phenylmethylsulfanylhypoxanthine 
• 5446-89-9 2-methylthioxanthine 
• 5446-89-9 2-Methylthio-6-hydroxy-purin 
• 66191-23-9 2-methylthio-6-chloropurine 
• 51998-91-5 2-benzylmercapto-6-chloropurine 
• 1255942-71-2 2-benzylmercapto-6-(2-hydroxy-3-methoxybenzylamino)purine 
• 142581-06-4 2-((4-chlorophenyl)amino)-1,9-dihydro-6H-purin-6-one 

Relevant articles and documents

2-Alkyloxyalkylthiohypoxanthines as new potent inhibitors of xanthine oxidase.

The title compounds were prepared and tested as xanthine oxidase (XO) inhibitors. Results evidenced that potency was related to the position of the oxygen atom in the 2-linear chain and that it grew with distance from the sulfur atom until it became equipotent to 2-n-hexylthiohypoxanthine. Enzymatic oxidation on C(2) occurred in the 8-alkylthiohypoxanthines. On the contrary, oxidation on C(8) did not occur in the 2-alkythioderivatives, demonstrating that the chain forced these molecules to form a complex with molybdenum(VI) involving only the N(3) and N(9) nitrogen atoms.

POTASSIUM CHANNEL MODULATORS

Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with potassium channels.

SUBSTITUTED 6-(BENZYLAMINO) PURINE RIBOSIDE DERIVATIVES, USE THEREOF AND COMPOSITIONS CONTAINING THESE DERIVATIVES

The invention relates to 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities. The invention relates also to the compositions, which contain these derivatives as active ingredients. ˙