2488-53-1 Usage
Description
4-(Difluoromethylsulfonyl)chlorobenzene is a chlorobenzene derivative featuring a difluoromethylsulfonyl group attached to the benzene ring. It is recognized for its reactivity and potential as a building block in the synthesis of complex organic molecules, which allows for the modification of the chemical and physical properties of the resulting products. This chemical compound is utilized in various industrial applications, including the production of pharmaceuticals, agrochemicals, and specialty chemicals.
Uses
Used in Pharmaceutical Industry:
4-(Difluoromethylsulfonyl)chlorobenzene is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity contribute to the development of new drugs with improved therapeutic properties and efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(Difluoromethylsulfonyl)chlorobenzene serves as an essential building block for the creation of novel agrochemicals. Its incorporation into these compounds can enhance their performance, selectivity, and environmental compatibility.
Used in Specialty Chemicals Industry:
4-(Difluoromethylsulfonyl)chlorobenzene is utilized as an intermediate in the production of specialty chemicals, such as dyes and polymers. Its presence in these compounds can alter their properties, leading to the development of innovative materials with specific characteristics and applications.
Used in Organic Synthesis:
4-(Difluoromethylsulfonyl)chlorobenzene is employed as a versatile reagent in organic synthesis, enabling the construction of complex organic molecules with diverse functional groups. Its reactivity and ability to modify the properties of the resulting products make it a valuable component in the synthesis of advanced organic compounds.
It is crucial to handle and use 4-(Difluoromethylsulfonyl)chlorobenzene with proper safety precautions and in a controlled environment to minimize potential hazards to health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 2488-53-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2488-53:
(6*2)+(5*4)+(4*8)+(3*8)+(2*5)+(1*3)=101
101 % 10 = 1
So 2488-53-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClF2O2S/c8-5-1-3-6(4-2-5)13(11,12)7(9)10/h1-4,7H
2488-53-1Relevant articles and documents
Method for constructing fluorine-containing methyl sulfone compound through multi-component coupling
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Paragraph 0121-0124, (2021/10/27)
The invention discloses a fluorine-containing methyl sulfone compound as shown in a formula (1) and a synthesis method thereof. Aromatic iodide (aryl iodide or heteroaryl iodide), an inorganic sulfur reagent and a fluorine-containing building block are used as reaction raw materials and react in a solvent under the action of alkali, a catalyst and an additive to obtain a series of fluorine-containing methyl sulfone compounds. According to the invention, the fluorine-containing sulfone compound is constructed by a one-pot two-step method by taking an inorganic sulfur reagent as a sulfur source under a catalytic condition, so that the defects of the traditional synthesis of a fluorine-containing sulfone compound by thioether oxidation are avoided. According to the synthesis strategy developed by the invention, some clinical methyl sulfone drugs can be modified, and monofluoro, difluoro and trifluoromethyl sulfone compounds can be successfully obtained, which have huge potential in the field of drug development in the future.
Efficient asymmetric synthesis of aryl difluoromethyl sulfoxides and their use to access enantiopure α-difluoromethyl alcohols
Batisse, Chloé,Céspedes Dávila, Maria F.,Castello, Marco,Messara, Amélia,Vivet, Bertrand,Marciniak, Gilbert,Panossian, Armen,Hanquet, Gilles,Leroux, Frédéric R.
supporting information, p. 3063 - 3079 (2019/05/07)
The -CHF2 moiety has shown a growing interest in pharmaceutical and agrochemical applications over the last few years. Its introduction is therefore a current research topic for organic chemists. Several groups have reported the synthesis of di
Difluoromethylation of: N -arylsulfonyl hydrazones with difluorocarbene leading to difluoromethyl aryl sulfones
Zheng, Qu-Tong,Wei, Yun,Zheng, Jian,Duan, Ya-Ya,Zhao, Gang,Wang, Zong-Bao,Lin, Jin-Hong,Zheng, Xing,Xiao, Ji-Chang
, p. 82298 - 82300 (2016/09/09)
The difluoromethylation of N-arylsulfonyl hydrazones with difluorocarbene generated from difluoromethylene phosphobetaine (Ph3P+CF2CO2-) to give various difluoromethyl aryl sulfones is described.
