2491-17-0

Basic information

• Product Name: 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE
• Synonyms: 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE;1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHYL-P-TOLUENESULFONATE;1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHYL-P-TOLUENESULPHONATE;LABOTEST-BB LT00159505;CMC METHO-P-TOLUENESULFONATE;N-CYCLOHEXYL-N'-(2-MORPHOLINOETHYL)CARBODIIMIDE METHYL-P-TOLUENESULFONATE;N-CYCLOHEXYL-N'-(2-MORPHOLINYL-(4)-ETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE;N-CYCLOHEXYL-N'-[BETA-(N-METHYLMORPHOLINO)-ETHYL]CARBODIIMIDE P-TOLUENESULFONATE SALT
• CAS NO: 2491-17-0
• Molecular Formula: C₇H₇O₃S*C₁₄H₂₆N₃O
• Molecular Weight: 423.57
• EINECS: 219-650-3
• Product Categories: Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Synthetic Organic Chemistry
• Mol File: 2491-17-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 115-120 °C
• Appearance: White to slightly yellow/Powder
• Density: 1.1302 (rough estimate)
• Refractive Index: 1.6320 (estimate)
• Storage Temp.: −20°C
• Water Solubility: Soluble in water
• CAS DataBase Reference: 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE(2491-17-0)
• EPA Substance Registry System: 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE(2491-17-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 2491-17-0(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow powder

Uses

Employed in a facile sequencing technique for pseudouridylate residues in RNA.

InChI:InChI=1/C14H26N3O.C7H8O3S/c1-17(9-11-18-12-10-17)8-7-15-13-16-14-5-3-2-4-6-14;1-6-2-4-7(5-3-6)11(8,9)10/h14H,2-12H2,1H3;2-5H,1H3,(H,8,9,10)/q+1;

Upstream product

• 111681-32-4 1-cyclohexyl-3-(2-morpholin-4-yl-ethyl)-urea 
• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 
• 3173-53-3 Cyclohexyl isocyanate 
• 29326-79-2 (2-morpholin-4-yl-ethyl)-phosphoramidic acid diethyl ester 
• 15580-20-8 1-cyclohexyl-3-(2-morpholino-ethyl)-carbodiimide 
• 80-48-8 methyl p-toluene sulfonate 

Downstream Products

• 6778-36-5 O²,O⁵-dimethyl-L-arabinose 
• 4060-10-0 O²,O³-dimethyl-D-galactose 
• 4301-53-5 O²,O⁴-dimethyl-D-galactose 
• 4060-09-7 2.3.4-Tri-O-methyl-D-galactose 
• 15075-09-9 2.3.4.6-Tetra-O-methyl-D-mannose 
• 3615-47-2 2,3,4,6-tetra-O-methyl-D-glucose 

Relevant articles and documents

Preparation method of 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate

The invention provides a preparation method of 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate, and the method comprises the following steps: S1, adding N-(2-aminoethyl) morpholine into a first organic solvent, and dropwise adding cyclohexyl isocyanate to generate an intermediate 1; S2, carrying out intramolecular dehydration reaction on the intermediate 1 to obtain an intermediate 2; S3, enabling the intermediate 2 to react with methyl p-toluenesulfonate, so as to generate the 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate. According to the preparation method of the 1-cyclohexyl-2-(morpholinoethyl) carbodiimide methyl p-toluenesulfonate disclosed by the embodiment of the invention, a product with high purity can be smoothly obtained, and the method is good in operability, higher and stable in yield and easily available in raw materials.

Preparation of Carbodiimides Using Phase-Transfer Catalysis

A new method is described for the preparation of carbodiimides by dehydration of ureas with arenesulfonyl chlorides under solid-liquid phase-transfer catalytic (PTC) conditions using solid potassium carbonate as a base and a lipophilic quaternary ammonium salt as a catalyst.The method is generally applicable for the synthesis of disubstituted carbodiimides, but is especially useful for unsymmetrically substituted carbodiimides.The basic carbodiimides prepared were identified in the form of the more stable, crystalline quaternary salts.