250215-21-5

Basic information

• Product Name: N²-Z-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithine
• Synonyms: N²-Z-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithine
• CAS NO: 250215-21-5
• Molecular Weight: 794.813
• Mol File: 250215-21-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N²-Z-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-Z-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithine(250215-21-5)
• EPA Substance Registry System: N²-Z-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithyl-N⁵-acetyl-N⁵-O-acetyl-L-ornithine(250215-21-5)

Safety Data

• Hazardous Substances Data: 250215-21-5(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 13650-49-2 N^δ-(tert-butoxycarbonyl)-L-ornithine 
• 7733-29-1 Z-Orn(Boc)-OH 
• 250215-13-5 (S)-2-{(S)-2-[(S)-2-(benzyloxycarbonylamino)-5-(tertbutoxycarbonylamino)valerylamino]-5-(tert-butoxycarbonylamino)valerylamino}-5-(tert-butoxycarbonylamino)valeric acid 
• 250215-17-9 (S)-2-((S)-2-((S)-2-Benzyloxycarbonylamino-5-{[1-phenyl-meth-(E)-ylidene]-amino}-pentanoylamino)-5-{[1-phenyl-meth-(E)-ylidene]-amino}-pentanoylamino)-5-{[1-phenyl-meth-(E)-ylidene]-amino}-pentanoic acid 

Relevant articles and documents

General Approach to Direct Measurement of the Hydration State of Coordination Complexes in the Gas Phase: Variable Temperature Mass Spectrometry

The formation of ternary aqua complexes of metal-based diagnostics and therapeutics is closely correlated to their in vivo efficacy but approaches to quantify the presence of coordinated water ligands are limited. We introduce a general and high-throughput method for characterizing the hydration state of para- and diamagnetic coordination complexes in the gas phase based on variable-temperature ion trap tandem mass spectrometry. Ternary aqua complexes are directly observed in the mass spectrum and quantified as a function of ion trap temperature. We recover expected periodic trends for hydration across the lanthanides and distinguish complexes with several inner-sphere water ligands by inspection of temperature-dependent speciation curves. We derive gas-phase thermodynamic parameters for discernible inner- and second-sphere hydration events, and discuss their application to predict solution-phase behavior. The differences in temperature at which water binds in the inner and outer spheres arise primarily from entropic effects. The broad applicability of this method allows us to estimate the hydration states of Ga, Sc, and Zr complexes under active preclinical and clinical study with as-yet undetermined hydration number. Variable-temperature mass spectrometry emerges as a general tool to characterize and quantitate trends in inner-sphere hydration across the periodic table.

Practical synthesis of hydroxamate-derived siderophore components by an indirect oxidation method and syntheses of a DIG-siderophore conjugate and a biotin-siderophore conjugate

A practical large-scale synthesis of hydroxamate-derived siderophore components (30 and 40) that utilizes an efficient indirect oxidation method is described and applied to the syntheses of nonradioactive labeled siderophores. Oxidation of imines derived from L-ornithine (17) and its tripeptide (19) afforded oxaziridines that were isomerized to stable nitrones (16 and 18). Acid-catalyzed hydrolysis of nitrones provided hydroxylamines that were converted to the desired hydroxamic acids (30 and 40) suitable for constructing siderophore-drug conjugates (2). The entire synthetic sequence required no chromatographic separation. DIG- and biotin-labeled ferrichrome analogues designed to detect and isolate ferrichrome receptors in various microbes were also synthesized.