25050-22-0

Basic information

• Product Name: Benzamide, N-(3,5-dimethylphenyl)-
• CAS NO: 25050-22-0
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol File: 25050-22-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(3,5-dimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(3,5-dimethylphenyl)-(25050-22-0)
• EPA Substance Registry System: Benzamide, N-(3,5-dimethylphenyl)-(25050-22-0)

Safety Data

• Hazardous Substances Data: 25050-22-0(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 108-69-0 3,5-dimethylaminoaniline 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 55-21-0 benzamide 
• 258278-25-0 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride 
• 141556-45-8 1,3-bis(mesityl)imidazolium chloride 
• 4406-77-3 2-Phenyl-1,3,2-dioxaborinane 
• 54132-75-1 3,5-dimethylphenyl isocyanate 
• 98-80-6 phenylboronic acid 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 172975-69-8 3,5-dimethylphenyl boronic acid 
• 99-94-5 p-Toluic acid 

Downstream Products

• 124043-95-4 N-benzyl-3,5-dimethylaniline 
• 65001-49-2 (E)-3,5-Dimethyl-2-(1'-propenyl)-anilin 
• 65001-48-1 (Z)-3,5-Dimethyl-2-(1'-propenyl)-anilin 
• 65001-46-9 2-allyl-3,5-dimethylaniline 
• 65001-45-8 N-allyl-3,5-dimethylbenzenamine 
• 502161-87-7 3-[benzyl-(3,5-dimethylphenyl)-amino]-cyclohex-2-enone 
• 502161-89-9 3-[benzyl-(3,5-dimethylphenyl)-amino]-cyclopent-2-enone 
• 51625-18-4 N-Allyl-N-benzoyl-3,5-dimethyl-anilin 

Relevant articles and documents

Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)

This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl fluorides can be formed from a range of acids under mild conditions. We also demonstrate that PFP can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides in yields of ≤94%.

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.

Base-Promoted Amidation and Esterification of Imidazolium Salts via Acyl C-C bond Cleavage: Access to Aromatic Amides and Esters

Imidazolium salts have been effectively employed as suitable acyl transfer agents in amidation and esterification in organic synthesis. The weak acyl C(O)-C imidazolium bond was exploited to generate acyl electrophiles, which further react with amines and alcohols to afford amides and esters. The broad substrate scope of anilines and benzylic amines and base-promoted conditions are the benefits of this route. Interestingly, phenol, benzylic alcohols, and a biologically active alcohol can also be subjected to esterification under the optimized conditions.