250681-53-9

Basic information

• Product Name: N-(3-amino-4-methylphenyl)-3-morpholinobenzamide
• Synonyms: N-(3-amino-4-methylphenyl)-3-morpholinobenzamide
• CAS NO: 250681-53-9
• Molecular Weight: 311.384
• Mol File: 250681-53-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 469.9±45.0 °C(Predicted)
• Density: 1.244±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N-(3-amino-4-methylphenyl)-3-morpholinobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-amino-4-methylphenyl)-3-morpholinobenzamide(250681-53-9)
• EPA Substance Registry System: N-(3-amino-4-methylphenyl)-3-morpholinobenzamide(250681-53-9)

Safety Data

• Hazardous Substances Data: 250681-53-9(Hazardous Substances Data)

Upstream product

• 221876-08-0 N-(3-morpholinobenzoyl)morpholine 
• 221876-07-9 3-morpholinobenzoyl chloride 
• 215309-00-5 3-(4-morpholinyl)benzoic acid 
• 119-32-4 4-Methyl-3-nitroanilin 
• 250681-52-8 N-(3-nitro-4-methylphenyl)-3-morpholinobenzamide 

Downstream Products

• 250681-33-5 N-[2-methyl-5-(3-morpholinobenzamido)phenyl]-3-chloromethylbenzamide 
• 250681-88-0 N-[2-methyl-5-(3-morpholinobenzamido)phenyl]-3-(1-tert-butoxycarbonylpyrrolidin-3-yloxy)benzamide 
• 250681-89-1 N-[2-methyl-5-(3-morpholinobenzamido)phenyl]-4-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzamide 
• 1395923-06-4 C₃₃H₃₁N₃O₃ 
• 250681-97-1 N-[2-methyl-5-(3-morpholinobenzamido)phenyl]-3-aminobenzamide 
• 250681-98-2 N-[2-methyl-5-(3-morpholinobenzamido)phenyl]-3-nitrobenzamide 
• 250681-56-2 N-[2-methyl-5-(3-morpholinobenzamido)phenyl]-4-benzyloxybenzamide 
• 258503-05-8 N-[2-methyl-5-(3-morpholinobenzamido)phenyl]thiophene-2-carboxamide 
• 250681-57-3 N-[2-methyl-5-(3-morpholinobenzamido)phenyl]-4-hydroxybenzamide 
• 334893-11-7 2-chloro-4-[2-methyl-5-(3-morpholinobenzamido)anilino]pyrimidine 

Relevant articles and documents

PYRIMIDINE DERIVATIVES

The invention concerns pyrimidine derivatives of Formula (I) wherein m is 0-3 and each Ris a group such as hydroxy, halogeno, trifluoromethyl and cyano; Ris hydrogen, halogeno or (1-6C)alkyl; n is 0-2 and each Ris a group such as hydroxy, halogeno, trifluoromethyl and cyano; p is 0-4; and Qis aryl or heteroaryl; or pharmaceutically acceptable salts or in vivo cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase

SAR studies led to the identification of 4-(3-benzoylamino-6-methyl- anilino)quinazolines as potent and selective inhibitors of p38 MAP kinase. Further optimisation led to the identification of a series of 4-(3-benzoylamino-6-methyl-anilino)pyrimidines as potent inhibitors of the p38 MAP kinase signalling pathway in vitro and in vivo. SAR studies led to the identification of 4-(3-benzoylamino-6-methyl-anilino)quinazolines as potent and selective inhibitors of p38 MAP kinase. Further optimisation led to the identification of a series of 4-(3-benzoylamino-6-methyl-anilino)pyrimidines as potent inhibitors of the p38 MAP kinase signalling pathway in vitro and in vivo.

BEZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES

The invention concerns the use of amide derivatives of formula (I) wherein: R1 and R2 are substituents such as hydroxy, C1-6alkoxy, mercapto, C1-6alkylthio, amino, C1-6alkylamino and di-(C1-6alkyl)amino; m and p are independently 0-3; R3 is C1-4alkyl; q is 0-4; and R4 is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines