250697-59-7

Basic information

• Product Name: 3-nitro-N-(2,3-dimethylphenyl)benzenesulfonamide
• Synonyms: 3-nitro-N-(2,3-dimethylphenyl)benzenesulfonamide
• CAS NO: 250697-59-7
• Molecular Weight: 306.342
• Mol File: 250697-59-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-nitro-N-(2,3-dimethylphenyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-nitro-N-(2,3-dimethylphenyl)benzenesulfonamide(250697-59-7)
• EPA Substance Registry System: 3-nitro-N-(2,3-dimethylphenyl)benzenesulfonamide(250697-59-7)

Safety Data

• Hazardous Substances Data: 250697-59-7(Hazardous Substances Data)

Upstream product

• 87-59-2 2,3-Dimethylaniline 
• 121-51-7 3-nitrobenzenesulphonyl chloride 

Downstream Products

• 244013-66-9 3-amino-N-(2,3-dimethylphenylbenzene sulphonamide) 

Relevant articles and documents

Different amino acid replacements in CAAX-tetrapeptide based peptidomimetic farnesyltransferase inhibitors

In a series of CAAX-tetrapeptide based farnesyltransferase inhibitors it has been shown that the central AA-dipeptide can be replaced by tranexamic acid, 4-aminobenzenesulfonic acid, and 3-amino-N-(2,3- dimethylphenyl)benzenesulfonamide, respectively, yielding inhibitors active in the low micromolar range. Lipophilic derivatives of these compounds showed moderate antiproliferative activity against different tumor cell lines. A promising class of peptidomimetic farnesyltransferase inhibitors was discovered through the replacement of the terminal AAX motif of the CAAX- tetrapeptide by 2-acylamino-5-aminobenzophenones.

Design, synthesis, and evaluation of novel modular bisubstrate analogue inhibitors of farnesyltransferase

Promising potential chemotherapeutics for the treatment of cancer can be developed from farnesyltransferase inhibitors. A novel class of modular bisubstrate farnesyltransferase inhibitors is presented that can be synthesized in a straightforward manner. A