250726-35-3Relevant articles and documents
Tetrahydroisoquinoline derivatives for treating protein trafficking diseases
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Page/Page column 16, (2008/06/13)
Tetrhydroisoquinoline derivatives, pharmaceutical compositions comprising them and methods of treating disease are disclosed herein. The disclosed compounds are useful in the treatment and prevention of diseases mediated by chloride channel activity and/or protein trafficking, including, but not limited to, diseases associated with impaired mucociliary clearance such as cystic fibrosis, bronchitis, emphysema, and the like.